Radiosynthesis, in vitro and preliminary biological evaluation of [18F]FABABA, a novel ASCT ‐2 inhibitor based PET tracer.

ConclusionsWe have successfully synthesized the radiotracer [18F]2 ‐amino‐4‐((2‐((3‐fluorobenzyl)oxy)benzyl)(2‐((3‐(fluoromethyl)benzyl)oxy)benzyl)amino)butanoic acid.In vitro experiments show a good affinity for both the human and rat ASCT ‐2. However, the tracer suffers from poorin vivo tumor uptake in the PC ‐3 model. Briefly, we present the first fluorine‐18 labelled derivative of compound V‐9302, a promising novel ASCT‐2 blocker used for inhibition of tumor growth.

Source: Journal of Labelled Compounds and Radiopharmaceuticals - May 29, 2020 Category: Biochemistry Authors: Tristan Baguet, Jakob Bouton, Jonas Janssens, Glenn Pauwelyn, Jeroen Verhoeven, Benedicte Descamps, Serge Van Calenbergh, Christian Vanhove, Filip De Vos Tags: RESEARCH ARTICLE Source Type: research