α 1-Adrenergic Receptor Blockade by Prazosin Synergistically Stabilizes Rat Peritoneal Mast Cells.

Conclusions: This study provided electrophysiological evidence for the first time that adrenaline dose-dependently inhibited the process of exocytosis, confirming its usefulness as a potent mast cell stabilizer. The pharmacological blockade of α 1-adrenergic receptor by prazosin synergistically potentiated such mast cell-stabilizing property of adrenaline, which is primarily mediated by β 2-adrenergic receptors.
PMID: 32461978 [PubMed - in process]

Source: Biomed Res - May 30, 2020 Category: Research Authors: Abe N, Toyama H, Ejima Y, Saito K, Tamada T, Yamauchi M, Kazama I Tags: Biomed Res Int Source Type: research