Evaluation of Zhenwu Decoction Effects on CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS.

In conclusion, the significant inductive effects of ZWD on three CYP450 isoenzymes indicated that when ZWD was coadministrated with drugs mediated by these enzymes, not only should the potential herb-drug interactions (HDIs) be observed, but the dosage adjustment and tissue drug concentration should also be considered. Furthermore, the approach described in this article can be applied to study the importance of gender, age, and disease factors to HDI prediction.
PMID: 32461991 [PubMed - in process]

Source: Biomed Res - May 30, 2020 Category: Research Authors: Hong LL, Wang Q, Zhao YT, Zhang S, Zhang KQ, Chen WD, Peng C, Liu L, Wang HS Tags: Biomed Res Int Source Type: research