Histopathology of Cutaneous Leishmaniasis Caused by Leishmania donovani in Sri Lanka.

Histopathology of Cutaneous Leishmaniasis Caused by Leishmania donovani in Sri Lanka. Biomed Res Int. 2020;2020:4926819 Authors: Wijesinghe H, Gunathilaka N, Semege S, Pathirana N, Manamperi N, de Silva C, Fernando D Abstract Cutaneous leishmaniasis (CL) is a neglected tropical disease that is gaining importance in Sri Lanka and internationally. The clinical presentation, pathology, and method of parasite elimination in CL vary according to the species. Leishmania donovani is the causative organism for leishmaniasis in Sri Lanka. This collaborative cross-sectional study describes the clinicopathological features of cutaneous leishmaniasis among personnel of the tri-forces serving in the North and East of the country. The histology of fifty cases of CL confirmed by at least two methods (slit skin smear, lesion aspirate, tissue impression, and histology) was reviewed. The parasitic load was assessed semiquantitatively. The histological features were correlated with the clinical presentation and organism load. The majority (89.8%; n = 44) presented with a single lesion mostly located in the upper limb (69.4%). The lesion types included papule (34.7%), nodule (32.7%), and an ulcer (30.6%). The evolution time of lesions averaged 31.55 weeks. Epidermal changes were observed in 49 of the biopsies and included hyperkeratosis (90.0%; n = 45), acanthosis (44.0%; n = 22), atrophy (34.0%; n = 17), and interface change (66%; n = 33). Dermal chang...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research