A New Computer-Aided Diagnosis System with Modified Genetic Feature Selection for BI-RADS Classification of Breast Masses in Mammograms.

A New Computer-Aided Diagnosis System with Modified Genetic Feature Selection for BI-RADS Classification of Breast Masses in Mammograms. Biomed Res Int. 2020;2020:7695207 Authors: Boumaraf S, Liu X, Ferkous C, Ma X Abstract Mammography remains the most prevalent imaging tool for early breast cancer screening. The language used to describe abnormalities in mammographic reports is based on the Breast Imaging Reporting and Data System (BI-RADS). Assigning a correct BI-RADS category to each examined mammogram is a strenuous and challenging task for even experts. This paper proposes a new and effective computer-aided diagnosis (CAD) system to classify mammographic masses into four assessment categories in BI-RADS. The mass regions are first enhanced by means of histogram equalization and then semiautomatically segmented based on the region growing technique. A total of 130 handcrafted BI-RADS features are then extracted from the shape, margin, and density of each mass, together with the mass size and the patient's age, as mentioned in BI-RADS mammography. Then, a modified feature selection method based on the genetic algorithm (GA) is proposed to select the most clinically significant BI-RADS features. Finally, a back-propagation neural network (BPN) is employed for classification, and its accuracy is used as the fitness in GA. A set of 500 mammogram images from the digital database for screening mammography (DDSM) is used for evaluation. Our system achieves ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research

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Condition:   Breast Cancer Interventions:   Diagnostic Test: tomosynthesis + synthetic 2D;   Diagnostic Test: digital mammography Sponsors:   Azienda Unità Sanitaria Locale Reggio Emilia;   AULSS 9 Scaligera di Verona;   IRCCS Policlinico S. Donato, Milano;   Azienda Ospedaliera Universitaria Integrata Verona Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we assessed multiplicative interactions between MD measures and established risk factors on the risk of invasive breast cancer overall and by menopausal and estrogen receptor (ER) status. We used data on 2,137 cases and 4,346 controls from a nested case-control study within the Nurses' Health Studies I (1976-2004) and II (1989-2007), for whose data on percent mammographic density (PMD), absolute area of dense tissue (DA) and non-dense tissue (NDA) were available. No interaction remained statistically significant after adjusting for number of comparisons. For breast cancer overall, we observed nominally signi...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
CONCLUSION: Breast ultrasound shows a high sensitivity to detect breast cancer during pregnancy. BCP is diagnosed at a higher stage than in nonpregnant women. In our series, patients with BCP had poorer outcomes than the not pregnant group. These results were not observed when adjusting for stage. PMID: 32623975 [PubMed - as supplied by publisher]
Source: Tumori - Category: Cancer & Oncology Tags: Tumori Source Type: research
CONCLUSIONS: Early initiation (at ages 25 to 30 years) of annual breast cancer screening with MRI, with or without mammography, might reduce breast cancer mortality by half or more in survivors of childhood cancer. PRIMARY FUNDING SOURCE: American Cancer Society and National Institutes of Health. PMID: 32628531 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
(American College of Physicians) Early initiation (at ages 25 to 30) of annual breast cancer screening with breast MRI, with or without mammography, might reduce breast cancer mortality by half or more in female survivors of childhood cancer previously exposed to chest radiation. These findings highlight the importance of MRI in reducing deaths from breast cancer in this population. A comparative modeling study is published in Annals of Internal Medicine.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Abstract Overseas, the importance for breast MRI screening for high-risk groups has been shown. However, the evidence among Japanese population was lacking. Therefore, we collaborated with the "Study on clinical and genetic characterization of hereditary breast and ovarian cancer and improvement in prognosis using genetic information in Japan" group, as part of the Comprehensive Research Project on the Promotion of Cancer Control, Health and Labour Sciences Research, and have been conducting the study entitled, "Study of the usefulness of MRI surveillance of BRCA1/2 mutation carriers" since 201...
Source: Breast Cancer - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research
by Thuy T. T. Le, Frederick R. Adler The benefits of mammography screening have been controversial, with conflicting findings from various studies. We hypothesize that unmeasured heterogeneity in tumor aggressiveness underlies these conflicting results. Based on published data from the Canadian National Breast Screening Study (CNBSS) , we develop and parameterize an individual-based mechanistic model for breast cancer incidence and mortality that tracks five stages of breast cancer progression and incorporates the effects of age on breast cancer incidence and all-cause mortality. The model accurately reproduces the report...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
Abstract BACKGROUND: The low subject contrast between cancerous and fibroglandular tissue could obscure breast abnormalities. PURPOSE: To investigate radiologists' performance for detection of breast cancer in low and high mammographic density (MD) when cases are digitally acquired. MATERIAL AND METHODS: A test set of 60 digital mammography cases, of which 20 were cancerous, were examined by 17 radiologists. Mammograms were categorized as low (≤50%) or high (>50%) MD and rated for suspicion of malignancy using the Royal Australian and New Zealand College of Radiology (RANZCR) classification system....
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research
Publication date: Available online 3 July 2020Source: European Journal of RadiologyAuthor(s): Dorothy Ibifuro Makanjuola, Abdulmohsen Alkushi, Khalid Al Anazi
Source: European Journal of Radiology - Category: Radiology Source Type: research
Conclusion: SRS, combined with SHG, can be a valuable tool in better understanding calcifications in carcinogenesis, diagnosis, and possible prognosis. This study not only reveals previously unknown large variations of breast microcalcifications in association with local malignancy but also corroborates the clinical value of linking microcalcification chemistry to breast malignancy. More importantly, it represents an important step in the development of a label-free imaging strategy for breast cancer diagnosis with tremendous potential to address major challenges in diagnostic discordance in pathology.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
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