Cancers, Vol. 12, Pages 1413: Prognostic Implications of CD10 and CD15 Expression in Papillary Thyroid Carcinoma
Cancers, Vol. 12, Pages 1413: Prognostic Implications of CD10 and CD15 Expression in Papillary Thyroid Carcinoma
Cancers doi: 10.3390/cancers12061413
Authors:
Eun Ji Oh
Andrey Bychkov
Haejin Cho
Tae-Min Kim
Ja Seong Bae
Dong-Jun Lim
Chan Kwon Jung
Patients with papillary thyroid carcinoma (PTC) have excellent survival, but recurrence remains a major problem in the management of PTC. We aimed to determine the prognostic impact of the expression of CD10 and CD15 in patients with PTC. Immunohistochemistry for CD10 and CD15 was performed on the tissue microarrays of 515 patients with PTC. The expression of CD10 and CD15 was detected in 201 (39.0%) and 295 (57.3%) of 515 PTC cases, respectively, but not in the adjacent benign thyroid tissue. Recurrence was inversely correlated with CD15 expression (p = 0.034) but not with CD10 expression. In 467 PTC patients treated with radioiodine remnant ablation, the CD15 expression had an adjusted hazard ratio of 0.500 (p = 0.024) for recurrence-free survival and an adjusted odds ratio of 2.678 (p = 0.015) for predicting long-term excellent therapeutic response. CD10 expression was not associated with clinical outcomes. In the Cancer Genome Atlas dataset, the expression level of FUT4 (CD15) mRNA was higher in the low/intermediate-risk group for recurrence than in the high-risk group and exhibited positive correlation with SLC5A5 (NIS) mRNA expression (p = 0.003). Taken together, CD15 expression was identified as an indepen...
Source: Cancers - Category: Cancer & Oncology Authors: Eun Ji Oh Andrey Bychkov Haejin Cho Tae-Min Kim Ja Seong Bae Dong-Jun Lim Chan Kwon Jung Tags: Article Source Type: research