Alteration of glycosylation as a biomarker for invasive pneumococcal disease

Worldwide use of pneumococcal conjugate vaccines (PCVs) had reduced the incidence of pneumonia and invasive pneumococcal disease (IPD) in children.1,2 Despite increasing vaccine coverage and a reduction in the prevalence of IPD, Streptococcus pneumoniae remains a significant cause of non-Shiga toxin-producing Escherichia coli hemolytic uremic syndrome (HUS) in children.3 HUS is characterized by the presence of the clinical triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Editorial Source Type: research

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Publication date: Available online 4 July 2020Source: European UrologyAuthor(s): Amit Bansal, Anant Kumar
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 4 July 2020Source: European UrologyAuthor(s): Lan Zhu, Gang Chen
Source: European Urology - Category: Urology & Nephrology Source Type: research
Discussion Biometrics uses “biological characteristics or behavioral features to recognize an individual.” Using biometric data requires acquisition of data of sufficient quantity and quality for recognition and comparison, and the biometric data needs to remain stable over time (i.e. – the person should be able to be recognized in the future using the data. Data acquisition and storage cost and size are also important variables. Privacy and security are also paramount considerations. Biometrics use in pediatric patients has several applications including: Newborn tracking -using biometrics for iden...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Publication date: Available online 4 July 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Petar Radanliev, David De Roure, Rob Walton
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 4 July 2020Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Yuefei Zhu, Jia Li, Zhiqing Pang
Source: Asian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research
ConclusionsIncident reports identified neonates, a shortlist of drugs, and specific error types, associated with modifiable behaviors, as priority improvement targets. These findings direct further study and inform intervention development, such as specific training in calculations to prevent dosing errors. Involving experienced practitioners both endorsed the findings and engaged the practice community in their future implementation. The utility of incident reports to direct improvement efforts may offset the limitations in their representativeness.
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
AbstractThe aims of this work were to identify in vivo manifestations of antioxidant activity ofLactobacillus strains isolated from healthy human biotopes and to show the possibility of protective action of the selected strain on the model of oxidative stress induced by paraquat in the model of early Parkinson ’s disease (PD) in mice. We studied the protective effects of 14Lactobacillus strains belonging to five species on the lifespan of the soil nematodeCaenorhabditis elegans experiencing oxidative stress induced by paraquat. TheLactobacillus strains used in this study were selected previously based on their abilit...
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
BOSTON (CBS) – Massachusetts is set to enter Phase 3 of its coronavirus reopening plan on Monday, meaning a new wave of businesses will be eligible to open their doors. Gov. Charlie Baker announced Thursday that the state would move forward into the next portion of the plan. The governor said Phase 3 is expected to last longer than previous phases. So what can reopen on Monday? Gyms and fitness centers can open with occupancy under 40%. They must sanitize equipment between use and require face coverings. Professional sports teams can host games, but not with fans. The Red Sox have opened Fenway Park for “summer...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Closures Covid-19 Boston, MA Featured Health Syndicated Local Coronavirus Gov. Charlie Baker Source Type: news
Publication date: Available online 5 July 2020Source: Medical Mycology Case ReportsAuthor(s): Norma B. Fernandez, Diego H. Caceres, Karlyn Beer, Celica Irrazabal, Ghilka Delgado, Luciana Farias, Tom M. Chiller, Paul E. Verweij, Daniel Stecher
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
Abstract 6,6'-Aryl trehalose derivatives have been synthesized with a view towards identifying novel Th-17-inducing vaccine adjuvants based on the high affinity Mincle ligand Brartemicin. The initial structure-activity relationships of these novel trehalose-based compounds were investigated. All compounds have been evaluated for their ability to engage the Mincle receptor and induce a potential pro-Th17 cytokine profile from human peripheral blood mononuclear cells based on IL-6 production in human peripheral blood mononuclear cells. The preliminary biological characterization of the designed analogs presented in ...
Source: Bioorganic and Medicinal Chemistry - Category: Chemistry Authors: Tags: Bioorg Med Chem Source Type: research
More News: Anemia | Children | Gastroenteritis | Hemolytic Uremic Syndrome (HUS) | Meningitis Vaccine | Microangiopathic Hemolytic Anemia | Pediatrics | Perinatology & Neonatology | Pneomococcal Vaccine | Pneumonia | Thrombocytopenia | Urology & Nephrology | Vaccines