Redox State Control of Human Cytoglobin by Direct Electrochemical Method to Investigate its Function in Molecular Basis.

Redox State Control of Human Cytoglobin by Direct Electrochemical Method to Investigate its Function in Molecular Basis.
Chem Pharm Bull (Tokyo). 2020 May 26;:
Authors: Mie Y, Takahashi K, Torii R, Jingkai S, Tanaka T, Sueyoshi K, Tsujino H, Yamashita T
Abstract
The direct electron transfer between human cytoglobin (Cygb) and the electrode surface, which would allow manipulating the oxidation states of the heme iron in Cygb, was first observed by immobilizing Cygb on a nanoporous gold (NPG) electrode via a carboxy-terminated alkanethiol. The voltammetric performances of the wild type and mutated Cygb-immobilized NPG electrodes were evaluated in the absence or presence of potential substrates. The obtained results demonstrated that the usefulness of the proposed method in understanding the function of Cygb in molecular basis.
PMID: 32461519 [PubMed - as supplied by publisher]

Source: Chemical and Pharmaceutical Bulletin - May 25, 2020 Category: Drugs & Pharmacology Authors: Mie Y, Takahashi K, Torii R, Jingkai S, Tanaka T, Sueyoshi K, Tsujino H, Yamashita T Tags: Chem Pharm Bull (Tokyo) Source Type: research