Anti –Saccharomyces cerevisiae antibodies could reflect distinct phenotypes in hidradenitis suppurativa

In their recent publication Assan et  al1 have shown that both IgG and IgA anti–Saccharomyces cerevisiae antibodies (ASCAs) are associated with hidradenitis suppurativa (HS).1 As the authors state, ASCA positivity has long been associated with Crohn disease and has recently been identified as a biomarker for spondyloarthritis (SpA). However, both Crohn disease and SpA comprise distinct phenotypes. The phenotype in Crohn disease can change from an inflammatory phenotype, to a fibrostenotic or penetrating phenotype with respectively severe stricturing or fistulation.

Source: Journal of Allergy and Clinical Immunology - May 28, 2020 Category: Allergy & Immunology Authors: Kelsey R. van Straalen Tags: Correspondence Source Type: research