FDA Approves First Diagnostic Drug for Imaging Tau to Help Detect Alzheimer ’s Disease

In this study, five new evaluators reviewed each other’s readings of the scans, and the researchers rated how well the evaluators agreed with one another’s assessments. Perfect agreement was scored as 1, and no agreement was scored as 0. Agreement was 0.87 across all 241 patients.The most common side effects were headache, pain at the injection site, and increased blood pressure, with all side effects occurring in less than 1.5% of the patients.Flortaucipir F18 was developed by Avid Radiopharmaceuticals Inc., a subsidiary of Eli Lilly and Co. In astatement, Lilly noted that availability of flortaucipir F18 will be limited initially and will expand in response to demand and coverage by insurers.Now inPsychiatric NewsPsychiatric News continues to report news and information relevant to psychiatrists about the COVID-19 pandemic. We will highlight these articles for you as they become available online:APA ’s Ethics Committee Responds to Questions Related to COVID-19Don ’t miss out! Learn whenPsychiatric News posts new articles by signing uphere.For previous news alerts,click here.
Source: Psychiatr News - Category: Psychiatry Tags: Alzheimer's disease Avid Radiopharmaceuticals cognitive impairment diagnostic Food and Drug Administration imaging protein tau tau neurofibrillary tangles Source Type: research

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Publication date: December 2020Source: Interdisciplinary Neurosurgery, Volume 22Author(s): Sabino Luzzi, Alice Giotta Lucifero, Stefano Marasco, Mattia Del Maestro, Giuseppe Bellantoni, Cristian Gragnaniello
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Authors: Rahaman MM, Saha O, Rakhi NN, Chowdhury MMK, Sammonds P, Kamal AM PMID: 32662750 [PubMed - as supplied by publisher]
Source: Pathogens and Global Health - Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research
Source: St. Michael's Hospital News and Media - Category: Hospital Management Tags: Hospital News Source Type: news
CONCLUSIONS: AS poses a significant burden for the Spanish National Health System and society. PMID: 32662412 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Akkoc N PMID: 32662406 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
In conclusion, male mice formed larger bone calluses than females during tibial fracture healing for both WT and mdx mice. This may be attributed to higher IGF-1 expression, activation of Wnt/β-catennin signaling pathway and greater OB numbers during callus formation. Female mice achieved better bone remodeling in the regenerated bone with higher bone quality due to increased OC numbers that promote faster remodeling of the fracture calluses, and higher BMP-9 expression levels. Therefore, gender is one of many factors that need to be considered for both animal and human bone research. PMID: 32655796 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Park CR, Song MG, Park JY, Youn H, Chung JK, Jeong JM, Lee YS, Cheon GJ, Kang KW Abstract Human serum albumin (HSA) accumulates in tumors by the enhanced permeability and retention (EPR) effect, which is a passive targeting effect in tumors. A recent study showed that secreted protein acidic and rich in cysteine (SPARC), an albumin-binding protein, mediates albumin accumulation in tumors. Arg-Gly-Asp (RGD) is a peptide targeting integrin αvβ3, which is highly expressed during tumor angiogenesis. We investigated whether conjugation of RGD to HSA could synergistically enhance tumor targeting. Accu...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Carvalho Vasconcelos R, Ferreira C, de Araújo EM, Motta F, Bomio M, de Araújo Júnior RF, Paiva DFF, Pirih FQ, da Silva JSP, Chan AB, Cruz LJ, Ishii M, de Medeiros CACX, Coelho Bernardo Guerra G, de Araújo AA Abstract The aim of this study was to characterize and evaluate zirconia/hydroxyapatite in a critical size calvarial defect model in rats. Zirconia/hydroxyapatite (80/20) scaffold was characterized by X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM). Critical size (8 mm) calvarial defects were created in wistar rats (n=48) and divided into four groups (90 days)...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Zhou W, Cai A, Nie B, Zhang W, Yang T, Zheng N, Manyande A, Wang X, Xu F, Tian X, Wang J Abstract Functional magnetic resonance imaging (fMRI) has been used extensively to understand the brain function of a wide range of neurological and psychiatric disorders. When applied to animal studies, anesthesia is always used to reduce the movement of the animal and also reduce the impacts on the results of fMRI. Several awake models have been proposed by applying physical animal movement restrictions. However, restraining devices were designed for individual subject which limits the promotion of fMRI in awake anim...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Alahdal M, Duan L, Ouyang H, Wang D Abstract Osteoarthritis (OA) is a chronic degenerative joint disease and a leading cause of disability. It involves articular cartilage destruction and a whole joint inflammation. In spite of OA pathogenesis is still unclear, new studies on the OA pathophysiological aetiology and immunomodulation therapy continuously achieve significant advances with new concepts. Here, we focus on the indoleamine-2,3-dioxygenase1 (IDO1) activity in the osteoarthritis (OA), which is one of the noticeable enzymes in the synovial fluid of arthritis patients. It was recognized as an essenti...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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