The differential effects of low dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension.

The differential effects of low dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension. Am J Physiol Renal Physiol. 2020 May 28;: Authors: Polina I, Domondon M, Fox R, Sudarikova A, Troncoso M, Vasileva V, Kashyrina Y, Beck Gooz M, Schibalski R, DeLeon-Pennell KY, Fitzgibbon WR, Ilatovskaya DV Abstract Diuretics and renin-angiotensin system (RAAS) blockers are often insufficient to control the blood pressure (BP) in salt-sensitive (SS) subjects. Abundant data support the proposal that level of Atrial Natriuretic Peptide (ANP) may correlate with pathogenesis of SS hypertension. We hypothesized here that increasing ANP level with sacubitril, combined with RAAS blockage by valsartan, can be beneficial for alleviation of renal damage in a model of SS hypertension, the Dahl SS rat. To induce a BP increase, the rats were challenged with a high salt 4% NaCl diet for 21 days, and chronic administration of vehicle or low dose sacubitril and/or valsartan (75 ug/day each) was performed. Urine flow, Na+ excretion and water consumption were increased on HS diet compared to starting point (0.4% NaCl) in all groups, but remained similar among the groups at the end of the protocol. Upon salt challenge, we observed a mild decrease in systolic BP and urinary NGAL levels (indicative of alleviated tubular damage) in the valsartan-treated groups. Sacubitril, as well as sacubitril/valsartan, attenuated GFR decline induced by the ...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research