NF- κB blockade during short-term L-NAME and salt overload strongly attenuates the late development of chronic kidney disease.

NF-κB blockade during short-term L-NAME and salt overload strongly attenuates the late development of chronic kidney disease. Am J Physiol Renal Physiol. 2020 May 28;: Authors: Carneiro Oliveira K, Fregnan Zambom FF, Albino AH, Costa Alarcon Arias S, Ferreira Ávila V, Dias Faustino V, Avancini Costa Malheiros DM, Olsen Saraiva Camara N, Kazue Fujihara C, Zatz R Abstract NO synthase inhibition by L-NAME plus high-salt diet (HS) is a model of Chronic Kidney Disease (CKD) characterized by marked hypertension and renal injury. With cessation of treatment, most of these changes subside, but progressive renal injury develops, associated with persistent low-grade renal inflammation. We investigated whether innate immunity, and in particular the NF-kB system, is involved in this process. Male Munich-Wistar rats received HS and L-NAME, 32 mg/Kg/d, while control rats received HS only. Treatment was ceased after Week 4 when 30 rats were studied. Additional rats were studied at Week 8 (n = 30) and Week 28 (n = 30). As expected, HS+L-NAME promoted severe hypertension, albuminuria, and renal injury after 4 weeks of treatment, whereas innate immunity activation was evident. After discontinuation of treatments, partial regression of renal injury and inflammation occurred, along with persistence of innate immunity activation at Week 8. At Week 28, glomerular injury worsened, while renal inflammation persisted and renal innate immunity remained acti...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research