Supplemental MRI Screening in Women with Very Dense Breasts Reduces Interval Cancer Rate but May Cause Overdiagnosis.

Supplemental MRI Screening in Women with Very Dense Breasts Reduces Interval Cancer Rate but May Cause Overdiagnosis. Am Fam Physician. 2020 Jun 01;101(11):695-696 Authors: Ebell MH PMID: 32463640 [PubMed - as supplied by publisher]
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research

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A prospective study of a urine and plasma biomarker test for the prediction of gleason ≥3 + 4 prostate cancer in a mixed cohort. Scand J Urol. 2020 Jul 01;:1-5 Authors: Poulsen MH, Feddersen S, Albitar M, Poulsen CA, Lund M, Pedersen TB, Mortensen MA, Lund L Abstract Purpose: Definitive diagnosis of prostate cancer is based on biopsies, a procedure associated with side-effects. The use of biomarkers in blood and urine could potentially help clinicians select patients for whom biopsies are needed. The aim of the study was to test a new urine and plasma biomarker test in detecting medium...
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
Conclusions: In this study, the conversion of maintenance immunosuppression from calcineurin inhibitors to mTOR inhibitors for clinical indications did appear to reduce the incidence of NMSC in kidney and liver transplant recipients. PMID: 32605413 [PubMed - in process]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Gamma linolenic acid suppresses hypoxia-induced gastric cancer cell growth and epithelial-mesenchymal transition by inhibiting the Wnt/β-catenin signaling pathway. Folia Histochem Cytobiol. 2020 Jul 01;: Authors: Wang Y, Shi J, Gong L Abstract INTRODUCTION: Gastric cancer is one of the most common malignancies in China and the fifth most common cancer in the world. Gamma linolenic acid (GLA) was reported to have anti-inflammatory and anti-cancer effects. The purpose of this research was to investigate the effect and mechanism of GLA on gastric cancer cell growth under hypoxic conditions. MATER...
Source: Folia Histochemica et Cytobiologica - Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research
Conclusion Patients were willing to trade off some degree of efficacy to avoid certain severity of side effects. It is therefore crucial for patients and physicians to discuss patients' preferences and circumstances to understand which attributes are more important, as well as patients' views on the trade-offs between treatment benefits and risks. PMID: 32609014 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Publication date: Available online 2 July 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Xuemei Xie, Yuan Li, Dezhang Zhao, Chunshu Fang, Dan He, Qiang Yang, Lin Yang, Ran Chen, Qunyou Tan, Jingqing Zhang
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
In conclusion, miR-369-3p inhibits the proliferation, migration and invasion of HCC cells by suppressing PAX6 expression. PMID: 32608213 [PubMed - as supplied by publisher]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Conclusion: We demonstrated the excellent properties of Pa-PEG nanodots that can be an in vivo imaging-guided PDT agent with renal clearable behavior for potential future clinical translation.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusions: In HER2+ BC oncogenic miR-429 is able to regulate HIF1α pathway by directly targeting VHL mRNA, a molecule important for the degradation of HIF1α. The overexpression of miR-429, observed in HER2+ BC, causes increased proliferation and migration of the BC cells. More important, silencing miR-429 succeeds in delaying tumor growth, thus miR-429 could be proposed as a therapeutic probe in HER2+ BC tumors.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Prostate-specific membrane antigen (PSMA)-targeted PET imaging for prostate cancer with 68Ga-labeled compounds has rapidly become adopted as part of routine clinical care in many parts of the world. However, recent years have witnessed the start of a shift from 68Ga- to 18F-labeled PSMA-targeted compounds. The latter imaging agents have several key advantages, which may lay the groundwork for an even more widespread adoption into the clinic. First, facilitated delivery from distant suppliers expands the availability of PET radiopharmaceuticals in smaller hospitals operating a PET center but lacking the patient volume to ju...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
Expression levels of biomarkers are generally unknown at initial diagnosis. The development of theranostic probes that do not rely on biomarker availability would expand therapy options for cancer patients, improve patient selection for nanomedicine and facilitate treatment of inoperable patients or patients with acquired therapy resistance. Herein, we report the development of star polymers, also known as nanostars, that allow for molecular imaging and/or endoradiotherapy based on passive targeting via the enhanced permeability and retention (EPR) effect.Methods: We synthesised a star copolymer, consisting of 7-8 centre-c...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
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