FDA Okays First Tau Radiotracer to Aid Alzheimer's Diagnosis FDA Okays First Tau Radiotracer to Aid Alzheimer's Diagnosis

Flortaucipir F18 (Tauvid) for use with PET imaging helps estimate the density and distribution of tau pathology in adults with cognitive impairment who are being evaluated for Alzheimer ’ s disease.FDA Approvals
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Psychiatry News Alert Source Type: news

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An imaging technique that combines F-18 FDG PET and MRI was able to pinpoint...Read more on AuntMinnie.comRelated Reading: SNMMI 2020: How nuclear medicine handled COVID-19 SNMMI 2020: Medical students key to the specialty's future PET, MRI uncover women's predisposition to Alzheimer's PET/MRI shows inflammation link to mitral valve prolapse Biomarkers on PET, MRI show breast cancer risk
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Association seen between surgery with general anesthesia and mild cortical thinning, but not Aβ deposits
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Neurology, Psychiatry, Surgery, Anesthesiology & amp; Pain, Geriatrics, Journal, Source Type: news
Authors: Brenowitz WD, Kaup AR, Yaffe K Abstract INTRODUCTION: We created a summary score for multiple sensory (multisensory) impairment and evaluated its association with dementia. METHODS: We studied 1794 adults aged 70 to 79 who were dementia-free at enrollment and followed for up to 10 years in the Health, Aging, and Body Composition Study. The multisensory function score (0 to 12 points) was based on sample quartiles of objectively measured vision, hearing, smell, and touch summed overall. Risk of incident dementia and cognitive decline (measured by two cognitive tests) associated with the score were asses...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
This study tested the self-reported sleep characteristics associated with cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers in cognitively intact older adults. METHODS: The linear and non-linear regression analyses were conducted in 736 cognitively normal participants (mean [standard deviation; SD] age, 62.3 [10.5] years, range 40 to 88 years, 59% female) who had measurements of cerebrospinal fluid (CSF) amyloid beta (Aβ) and tTau proteins and sleep characteristics, after adjusting for age, gender, education, apolipoprotein E gene (APOE) ε4 status, and general cognition. RESULTS: Greater da...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Authors: Gentry MT, Lapid MI, Syrjanen J, Calvert K, Hughes S, Brushaber D, Kremers W, Bove J, Brannelly P, Coppola G, Dheel C, Dickerson B, Dickinson S, Faber K, Fields J, Fong J, Foroud T, Forsberg L, Gavrilova R, Gearhart D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grossman M, Haley D, Heuer H, Hsiung GY, Huey E, Irwin D, Jones D, Jones L, Kantarci K, Karydas A, Knopman D, Kornak J, Kramer J, Kukull W, Lucente D, Lungu C, Mackenzie I, Manoochehri M, McGinnis S, Miller B, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin K, Rascovsky K, Sengdy P, Shaw L, Tatton N, Taylor J, Toga A, Trojano...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
TUESDAY, July, 13, 2020 -- Older adults who have surgery with general anesthesia may experience a modest cortical thinning in the brain, but it does not appear to be tied to Alzheimer disease, according to a study recently published in the British...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Obesity and its immediate consequences, such as non-alcoholic fatty liver disease and type 2 diabetes, are associated with greater neuroinflammation and risk of dementia. Excess visceral fat tissue does its part to produce chronic inflammation throughout the body, but here researchers focus on a specific metabolic dysregulation in the liver that produces inflammation in the brain. That inflammation in turn drives a faster progression towards neurodegenerative conditions. The lesson here, as in so much of this research: don't get fat, don't stay fat. You won't like the consequences. Researchers have revealed the ca...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.0c00391
Source: ACS Chemical Neuroscience - Category: Neuroscience Authors: Source Type: research
Contributors : Bodhisattwa Banerjee ; Debaprasad KonerSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioLong non-coding RNAs (lncRNAs) are now recognized as the master regulators of numerous biological processes. Hypoxia causes oxidative stress and severe and detrimental effects on brain function and acts as a critical initiating factor in the pathogenesis of Alzheimer ’s disease (AD). However, no data are available on the roles of lncRNAs and their target genes under hypoxia in the sub-regions of the fish brain. A group of zebrafish was exposed to hypoxic conditions (1.15±0...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research
ABSTRACT Objective Evaluate the accuracy of two semantic categories of the verbal fluency test (supermarket and animal categories) to separate healthy elderly individuals and lower educated Alzheimer ’ s disease patients. Methods We evaluated 69 older adults with less than 5 years of schooling, consisting of 31 healthy elderly, and 38 patients diagnosed with Alzheimer ’ s disease. Semantic verbal fluency was evaluated using the animal and supermarket categories. Mann-Whitney U and Independent t Tests were used to compare the two groups, and the diagnostic accuracy of the tests was analyzed by sensitivity, speci...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
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