Trans IL-6 signaling does not appear to play a role in renal scarring after urinary tract infection
While inflammation is an important innate defense mechanism against infection, it can also lead to local tissue damage. The trans signaling pathway of interleukin (IL)-6 is a known mediator of inflammation. We hypothesized that the trans IL-6 signaling pathway is associated with the development of post febrile urinary tract infection (UTI) renal scarring.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Sudipti Gupta, Guillermo Yepes Junquera, Lauren Nicassio, Brian Becknell, Christina B. Ching Source Type: research