Absence of Evidence Is Not the Evidence of Absence: Clinical Consideration when Interpreting Guidelines for the COVID-19 Pandemic

As the global prevalence of novel coronavirus 2019 (COVID-19) increases, with a death toll exceeding that during wartime, scientists and clinicians alike are racing against time to provide clarity on pathogenesis, mode of transmission, and to research potential treatment and vaccines amid the pandemic. In the meantime, hospital guidance1 is essential to protect health care providers (HCPs) and for disease containment. However, definitive guidelines are often elusive given the rapid emergence of new data and the time constraints for robust evidence.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Letter Source Type: research

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CONCLUSION: The modified Bateman SIZ model has been verified and used to predict the course of the COVID-19 pandemic in Heidelberg. Lockdown measures alone are insufficient to control the pandemic during 2021. Vaccination, diagnostic tests, and use of the Corona-Warn-App with quarantine could successfully control the spread of the coronavirus infection in the community. The Corona-Warn-App applied correctly may be the most effective. The model showed that vaccination with 50% efficacy is almost as effective as vaccination with 100% efficacy. PMID: 32646540 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
AbstractDuring the current COVID-19 pandemic, the global ratio between the dead and the survivors is approximately 1 to 10, which has put humanity on high alert and provided strong motivation for the intensive search for vaccines and drugs. It is already clear that if we follow the most likely scenario, which is similar to that used to create seasonal influenza vaccines, then we will need to develop improved vaccine formulas every year to control the spread of the new, highly mutable coronavirus SARS-CoV-2. In this article, using well-known RNA viruses (HIV, influenza viruses, HCV) as examples, we consider the main success...
Source: Inflammation Research - Category: Research Source Type: research
The novel human Coronavirus (SARS-CoV-2), which outbroke in Wuhan (China) in late 2019, is now responsible for the pandemic diffusion of COVID-19 [1 –3]. Researchers are working on the validation of effective protocols, including antiviral therapies and vaccines [4]. Case-fatality rate seems correlated with virally-driven hyperinflammation [4,5]. In this sense, recent data suggest a crucial role for cytokines release syndrome (CRS) and human i nterleukin-6 (IL-6) levels as fatality predictors [4,5].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: COVID-19 Rapid Letter Source Type: research
Billionaire philanthropist Bill Gates has called for COVID-19 drugs and an eventual vaccine to be made available to countries and people that need them most, not to the "highest bidder," saying relying on market forces would prolong the deadly pandemic.
Source: CBC | Health - Category: Consumer Health News Tags: News/World Source Type: news
CONCLUSIONS: It is anticipated that this review would certainly assist the public in general and scientific community in particular to recognize and effectively deal with COVID-19, providing a reference guide for futuristic studies. PMID: 32651959 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
(CNN) — If you want to be one of the first to receive an experimental vaccine for Covid-19, now’s your chance. Wednesday, a new website — coronaviruspreventionnetwork.org — went live allowing people in the United States to register to take part in clinical trials for vaccines and monoclonal antibody therapies. The website will handle registration for the four large vaccine studies that are expected to start this summer and fall, and any others that follow. The US Department of Health and Human Services announced the website Wednesday, along with the appointment of the Fred Hutchinson Cancer Research...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health CNN Coronavirus Coronavirus Vaccine Source Type: news
Covid-19 outbreak accelerates across Africa; Venezuelan Socialist Party boss also tests positive; Brazilian President Jair Bolsonaro ‘in good health’. Follow the latest updates:South Africa warns of coronavirus ‘storm’ as outbreak accelerates across continentBolivia ’s president and Venezuela’s Socialist party leader test positive for Covid-19WHO says coronavirus pandemic still acceleratingTrudeau and Trump ’s responses see wildly different results1.54amBSTPlans for the fall semester at the University ofCalifornia, Berkeley, are in question after 47 new Covid-19 cases tied to frate...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news UK news US news Australia news Science Infectious diseases Africa Microbiology Medical research Source Type: news
Abstract Recent reports suggest that routine childhood immunization coverage might have decreased during the coronavirus disease 2019 (COVID-19) pandemic (1,2). To assess the capacity of pediatric health care practices to provide immunization services to children during the pandemic, a survey of practices participating in the Vaccines for Children (VFC) program was conducted during May 12-20, 2020. Data were weighted to account for the sampling design; thus, all percentages reported are weighted. Among 1,933 responding practices, 1,727 (89.8%) were currently open; 1,397 (81.1%) of these reported offering immunizat...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
AbstractThe current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak, the cause of coronavirus disease (COVID-19), has influenced health globally. So far, there are no established management options and prophylaxis for those who have been exposed to SARS-CoV-2, and those who develop COVID-19. Documented scientific evidences in similar viral outbreaks in past suggested few therapy regimens. These rather have not shown promising results in management of current pandemic. So, in the current review, we are exploring novel treatment strategies and therapies that are being explored and are in clinical and pr...
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research
A recent pandemic caused by a single-stranded RNA virus, COVID-19, initially discovered in China, is now spreading globally. This poses a serious threat that needs to be addressed immediately. Genome analysis of SARS-CoV-2 has revealed its close relation to SARS-coronavirus along with few changes in its spike protein. The spike protein aids in receptor binding and viral entry within the host and therefore represents a potential target for vaccine and therapeutic development. In the current study, the spike protein of SARS-CoV-2 was explored for potential immunogenic epitopes to design multi-epitope vaccine constructs. The ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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