BuqitongluO Granule for Qi Deficiency and Blood Stasis Syndrome

Conditions:   Stroke, Ischemic;   Coronary Artery Disease;   Angina Pectoris, Stable;   Diabetic Peripheral Neuropathy Interventions:   Drug: Buqitongluo Granule;   Drug: Buqitongluo Granule Placebo;   Other: Standard care Sponsors:   Dongzhimen Hospital, Beijing;   The Affiliated Hospital of Changchun University of Chinese Medicine;   The Affiliated Hospital of Shandong University of Chinese Medicine;   The Affiliated Hospital of Chengdu University of Chinese Medicine;   The Second Affiliated Hospital of Tianjin Univer sity of Traditional Chinese Medicine;   The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine;   The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine;   The Second Affiliated Hospital of Hunan University of Traditional Chines e Medicine;   Hunan Academy of Traditional Chinese Medicine Affiliated Hospital;   The First Clinical Hospital of Jilin Academy of Traditional Chinese Medicine;   Shaanxi Buchang Pharmaceuticals Co., Ltd.;   Beijing Chuanglikechuang Medical Technology Development Co., Ltd.;   Shanghai Youn ingwei Biotechnology Co., Ltd.;   Wuhan Zhizhi Medical Technology Co., Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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CONCLUSIONS: In VFT analysis of SSNHL with dizziness, diverse patterns were identified. In the absence of SN, no definite vestibular organ involvement was the most frequent. But in the case with SN, posterior canal deficit was most common and cerebellar ischemic stroke was rare. PMID: 32623411 [PubMed - as supplied by publisher]
Source: Journal of Vestibular Research: Equilibrium and Orientation - Category: Neuroscience Tags: J Vestib Res Source Type: research
This secondary analysis of a randomized clinical trial assesses the subtype of recurrent ischemic stroke after embolic stroke of underdetermined source, the interaction with treatment assignment, and the consistency of cerebral location of the qualifying and recurrent strokes in the study population of the NAVIGATE-ESUS trial.
Source: JAMA Neurology - Category: Neurology Source Type: research
This systematic review and meta-analysis examines the recurrence of ischemic stroke and possible use of patent foramen ovale closure in patients aged 60 years or older.
Source: JAMA Neurology - Category: Neurology Source Type: research
AbstractEncephaloduroarteriosynangiosis (EDAS) is one of the most commonly used indirect vascular reconstruction methods. EDAS aids in the formation of collateral vessels from the extracranial to the intracranial circulation in patients with moyamoya disease (MMD). However, the underlying mechanism of collateral vessel formation is not well understood. Endothelial progenitor cells (EPCs) differentiate to form the vascular endothelial cells and play a very important role in angiogenesis. We designed this prospective clinical trial to investigate the presence of EPCs in patients with MMD and to explore the neovascularization...
Source: Translational Stroke Research - Category: Neurology Source Type: research
Ravindra K GargNeurology India 2020 68(3):560-572 COVID-19, in most patients, presents with mild flu-like illness. Elderly patients with comorbidities, like hypertension, diabetes, or lung and cardiac disease, are more likely to have severe disease and deaths. Neurological complications are frequently reported in severely or critically ill patients with comorbidities. In COVID-19, both central and peripheral nervous systems can be affected. The SARS-CoV-2 virus causes the disease COVID-19 and has the potential to invade the brain. The SARS-CoV-2 virus enters the brain either via a hematogenous route or olfactory system. A...
Source: Neurology India - Category: Neurology Authors: Source Type: research
We describe a 48-year-old male who presented with acute onset giddiness, mild dysarthria, right hemiparesis, and ataxia. Clinical examinations indicated left cerebellar signs with right hemiparesis. Additionally, the patient had significant clubbing and mild cyanosis. A strong family history of epistaxis and hemoptysis was noted. His Magnetic resonance imaging of the brain showed acute left cerebellar and left frontal cortical infarct with normal vessels. The routine stroke and cardiac workup were normal. Chest X-ray showed bilateral lower zone opacities. Contrast-enhanced computerized tomogram (CT) of the chest showed bil...
Source: Neurology India - Category: Neurology Authors: Source Type: research
AbstractHyperglycemia is a well-known indicator of stroke prognosis, and one-third of nondiabetic patients develop postischemic hyperglycemia during the acute phase of stroke; this is related to relatively poor prognosis, high mortality, and impaired neurological recovery. Interleukin-13 (IL-13), a member of the Th2 cytokine family, is involved in both the regulation of immune response and glucose metabolism. Thus, we investigated the mechanism of postischemic hyperglycemia and the role of IL-13 by using a permanent middle cerebral artery occlusion (MCAO) rat model. Our results indicated that postischemic hyperglycemia was...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
ConclusionsThe patients with high body weight, theCYP2C19 phenotypes, andP2Y12 receptor (52 G>T) variant alleles are at risk of CR during clopidogrel treatment in Chinese IS patients with aspirin intolerance. The higher body weight and relevant polymorphisms may help to predict CR in Chinese IS patients with aspirin intolerance.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
Abstract Recovery of motor function after stroke involves many biomarkers. This review attempts to identify the biomarker effects responsible for recovery of motor function following the use of Constraint-Induced Movement Therapy (CIMT) and discuss their implications for research and practice. From the studies reviewed, the biomarker effects identified include improved perfusion of motor areas and brain glucose metabolism; increased expression of proteins, namely, Brain-Derived Neurotrophic Factor (BDNF), Vascular Endothelial Growth Factor (VEGF), and Growth-Associated Protein 43 (GAP-43); and decreased level of G...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
We aimed to examine the association between baseline platelet count (PLT) and prognosis of acute ischemic stroke according to lipoprotein-associated phospholipase A2 (Lp-PLA2) mass.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
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