The Human Breast Milk Metabolome in Preeclampsia, Gestational Diabetes, and Intrauterine Growth Restriction: Implications for Child Growth and Development

Three complications of pregnancy —preeclampsia, gestational diabetes mellitus, and intrauterine growth restriction (IUGR)—are thought to share a common etiology, in which abnormal placental development and the resulting maternal inflammatory response play a key role.1 These 3 conditions, known as great obstetrical syndromes, ar e unfortunately quite common in pregnancy. However, the field of metabolomics has provided a rapid approach in identifying biomarkers predictive of their outcome.2,3
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Supplement Source Type: research

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Publication date: Available online 8 July 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Surabhi Mishra, Avinash Shetty, Chythra R. Rao, Sathisha Nayak, Asha Kamath
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Gestational diabetes mellitus (GDM) is defined as impaired glucose tolerance with onset or first recognition during pregnancy, which is characterized by an increased insulin resistance. Gestational diabetes me...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
CONCLUSION: Nearly one in five gestational carrier pregnancies in this cohort did not meet ASRM guidelines. Deviation from guidelines is associated with increased rate of cesarean delivery, neonatal morbidity, and preterm birth. Future research should focus on the safety of women who are gestational carriers and on why deviation occurs. PMID: 32649497 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Conclusion: Our study showed that, despite insulin treatment, pregnant women with T2D displayed a proinflammatory status consistent with high proportions of CD3+ and CD4+ T cells, upregulation of Th1 cytokines, and low IL-10 production, suggesting a reduced immune-suppressive activity of regulatory T cells. However, GDM, although associated with proinflammatory status, has shown increased humoral immunity consistent with high proportion of CD19+ B cells. Thus, the lack of response to insulin in diabetes during pregnancy and clinical implications of these immunological parameters deserves further investigations. PMID: 3...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Authors: Zhang C, Li Y, Wang J, Liu C, Chen Y Abstract Pregnant women with gestational diabetes mellitus (GDM) may have adverse pregnancy outcomes, even if their blood glucose level is well‑controlled. Aquaporin 3 (AQP3) and adiponectin (APN) serve important roles in fetal growth and development. However, the associations of AQP3 and APN with GDM and pregnancy outcome are not known. Therefore, the present study was performed to evaluate the expression of AQP3 in the placenta and APN in the umbilical artery blood, and the association of the two factors with GDM and pregnancy outcome. The patient cohort was di...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Effects of miR‑195‑5p on cell proliferation and apoptosis in gestational diabetes mellitus via targeting EZH2. Mol Med Rep. 2020 May 12;: Authors: Liao X, Zhou Z, Zhang X Abstract Gestational diabetes mellitus (GDM) is a type of diabetes mellitus (DM) that occurs during pregnancy. The present study aimed to investigate the roles of microRNA (miR)‑195‑5p and enhancer of zeste homolog 2 (EZH2) in GDM, and their potential association. Human umbilical vein endothelial cells (HUVECs) were collected from healthy and GDM umbilical cords, and the endothelial properties were detected by flow cytometry. ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
ConclusionWomen diagnosed with GDM have similar basal SNA versus normoglycemic pregnant women, but greater neurovascular transduction, meaning a greater influence of the sympathetic nerve activity in these women. We also document evidence of chemoreceptor hyperactivity, which may influence SNA in women with GDM but not in controls.
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
ConclusionThis study showed that the level of vitamin E is significantly lower in GDM women compared to healthy pregnant women.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
Abstract Gestational diabetes mellitus (GDM) increases the risk for short-term adverse perinatal outcomes for mothers and their infants. In addition, women with GDM are at increased risk for type 2 diabetes, and their offspring also face long-term risk for diabetes and obesity. Women who develop GDM have a high rate of recurrence in subsequent pregnancies. However, prevention of GDM remains a significant challenge. Weight gain during pregnancy has not been consistently associated with development of GDM, and dietary and physical activity interventions have shown only modest benefit in reducing the risk for GDM. ...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
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