The role of surgery in patients aged 85 years or older with resectable gastric cancer: a propensity score matching analysis of the SEER database.

This study aimed to explore the prognosis of a large sample of the oldest old GC patients receiving surgery.Methods: A total of 2914 oldest old patients with stage I-III GC were included in the linked Surveillance, Epidemiology, and End Results (SEER) database from 2006 to 2015. Based on their treatment, we assigned these patients to the surgery and no surgery groups. We used propensity score matching (1:1) to balance the baseline characteristics. The Kaplan-Meier method was used for the survival analysis. Multivariate Cox regression analysis was used to analyse the independent risk factors.Results: After propensity score matching, the median overall survival (OS) times in the surgery and no surgery groups were 24.0 (95% CI: 20.3-27.7) and 4.0 (95% CI: 3.5-4.5) months, respectively (p 
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

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Conclusions:The heterogeneity index-2 generated from baseline 18F-FDG PET/CT is significantly associated with survival outcomes of gastric-cancer patients. Preoperative assessment of HI-2 by 18F-FDG PET/CT may be a promising novel method for identifying patients with poor prognosis.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Gastrointestinal Liver and Non-GI Source Type: research
AbstractThe use of18F-fluorodeoxyglucose (FDG) positron emission tomography combined with computed tomography (PET/CT) is well established in the evaluation of alimentary tract malignancies. This review of the literature and demonstration of correlative images focuses on the current role of PET/CT in the diagnosis (including pathologic/clinical staging) and post-therapy follow-up of esophageal, gastric, and colorectal cancers. PET/CT provides utility in the management of esophageal cancer, including detection of distant disease prior to resection. In gastric cancer, PET/CT is useful in detecting solid organ metastases and ...
Source: Abdominal Imaging - Category: Radiology Source Type: research
By CHADI NABHAN, MD, MBA, FACP Have you thought about your own mortality? Who hasn’t, given the frequency of seeing death and grief depicted in the media or through real life encounters with friends, relatives, neighbors, or patients? These incidents trigger uncomfortable and sometimes uneasy thoughts of how we might personally deal with potential illness and disease. The same thoughts are soon displaced by the busyness of living.  Despite dealing with the death of his mother from a brain tumor, we learn David Fajgenbaum was healthy, living life to its fullest, and a future doctor in the making. He may...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Patients Physicians Book Review Chadi Nabhan Chasing My Cure Chasing My Cure book review David Fajgenbaum Mortality Outspoken Oncology Source Type: blogs
This study was designed to evaluate the effect of excision repair crosscomplementing group 1 (ERCC1) rs11615 codon 118C/T gene polymorphisms ontreatment outcomes in Iranian patients receiving oxaliplatin-based regimens forcolorectal (CRC) and gastric cancers (GC). Patients, who were candidates to receiveoxaliplatin-based chemotherapy, entered into the study. In 2-week intervals, thepatients received combination regimen of oxaliplatin, fluorouracil, and leucovorin(FOLFOX) for 3 months. ERCC1 rs11615 codon 118C/T polymorphism was testedby restriction fragment length polymorphism polymerase chain reaction (RFLPPCR)method usin...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
It’s in the early morning of April 15th, 2030 that when looking at your smart mirror, the latter beeps a warning notification: that new mole on your chin should be checked by your dermatologist. That was to be expected. After all your genetic test revealed that you possess a mutation in the CDKN2A gene. But you also get the recommendation to have your esophagus and stomach checked as your connected smart scale registered a noticeable drop in weight and this mutation also carries an increased risk of gastrointestinal (GI) tract cancer. With such increased awareness and early stage diagnosis methods, will the cance...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Personalized Medicine cancer digital health cancer treatment digital technology oncology cancer research cancer care digital health technologies Source Type: blogs
Rationale: Migration of endoclips and stitches into the duodenum after laparoscopic hepatectomy is incredibly rare with a poorly understood mechanism. Patient concerns: A 56-year-old woman who underwent laparoscopic left hepatectomy and cholecystectomy in August 2016 was admitted to our hospital with nausea and vomiting in December 2017. Diagnoses: Abdominal computed tomography (CT) scan showed high density shades in duodenal ampulla. Esophagogastroduodenoscopy showed deformation of the duodenal ampulla into two lumens; hem-o-lock clips and stitches were detected in the upper lumen. Contrast enhanced CT scan reveal...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Computed tomographic (CT) imaging at third lumbar vertebra (L3), routinely used by oncologists, represents a reliable tool to quantify muscle mass. A systematic review and meta-analysis was performed to assess the efficacy of CT scan to define muscle mass as a prognostic marker in GC patients undergoing gastrectomy and/or chemotherapy. The primary outcomes were overall survival (OS) and recurrence-free survival (RFS) and the secondary outcomes included postoperative length of hospital stay (P-LOS), total and severe complications in GC patients undergoing gastrectomy.
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Meta-analyses Source Type: research
CONCLUSIONEarly diagnosis and concerted therapeutic efforts are important for managing misdiagnosed metastatic gastric cancer.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We present the exact course of a spontaneous rupture of the eyeball with choroidal metastasis from gastric carcinoma (GC) and the applied surgical interventions. Patient concerns: A 59-year-old male presented with pain and vision loss on his left eye for 6 months. He was diagnosed with GC, for which he received systemic chemotherapy for a year. Diagnoses: Preoperative B-scan, color fundus photography, computed tomography, and magnetic resonance imaging showed a choroidal tumor in his left eye. The spontaneous rupture of the corneoscleral limbus from 2 to 5 o’clock, combined secondary glaucoma, exudative retinal...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
ConclusionsIn this analysis, nivo was not associated with HP in the pbo-controlled CheckMate 451 trial. These data are consistent with the previous analysis of ATTRACTION-2, suggesting that reports of HP with immunotherapy may reflect some patients ’ natural course of disease.Clinical trial identificationCheckMate 451 trial: NCT02538666.ONO-4538-12/ATTRACTION-2 trial: NCT02267343.Editorial acknowledgementStephen Gutkin and Jay Rathi, MA, of Spark Medica Inc, funded by Bristol-Myers Squibb.Legal entity responsible for the studyBristol-Myers Squibb and ONO Pharmaceutical Co. Ltd.FundingBristol-Myers Squibb and ONO Phar...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
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