Cigarette smoking is associated with high level of ferroptosis in seminal plasma and affects semen quality.

In this study, semen samples from 70 heavy smokers and 75 non-smokers receiving infertility treatment were included. Basic semen parameters in non-smokers and heavy smokers were evaluated. Levels of glutathione (GSH), lipid reactive oxygen species (ROS), iron and GSH-dependent peroxidase 4 (GPX4) protein level were observed in human seminal plasma and in GC-2Spd cells exposed to cigarette smoke condensate (CSC). RESULTS: Heavy smokers had significantly higher abnormalities (sperm viability and sperm progressive motility) than non-smoking counterparts. Comparing non-smokers group, GSH level was reduced in the group of heavy smokers (P 
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research

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Reproduction is an essential human right that transcends race, gender, sexual orientation, or country of origin. Infertility is the impairment of reproductive capacity; it is a serious disease that affects 8-12% of couples of reproductive age and harms physical and mental well-being. Infertility is time-sensitive, and prognosis worsens with age. While there is no cure for most causes, the disease is most often treatable, and the majority of patients who seek treatment can ultimately become parents.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: ASRM PAGES Source Type: research
In this study, we investigated the roles of 14‐3‐3η and 14‐3‐3ε isoforms in spermatogenesis.Materials and MethodsTo study thein vivo function of 14 ‐3‐3η and 14‐3‐3ε in spermatogenesis, we generated testis‐specific and global knockout mice for each of 14‐3‐3η and 14‐3‐3ε isoforms (CKO and GKO, respectively). Computer Assisted Semen Analysis was used to assess sperm motility, while immunohistochemical studies were conducted to check spermatogenesis.ResultsAlthough both 14 ‐3‐3η and 14‐3‐3ε isoforms were present in mouse testis, only the expres...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Many infertile couples are getting increasingly frustrated because of the lock down .They can ’t continue with their treatment because infertility clinics are closed. While ours is open, they can’t come to our clinic because of the Lockdown. Also, they are worried they may get COVID-19, because hospitals are hot-beds of the Coronavirus, and they want to avoid them.Everyone has been hopeful that the Lockdown will get over next week - or next month – but there seems to be no signs of it ending !The good news is that we have a treatment option for you – you can treat yourself at home using our Self-Ins...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Abstract Endometrial polyps have a reported prevalence from 7.8% up to 30% and are one of the most cost-consuming gynecological conditions for our specialty. There are strong practitioner beliefs that surgical removal of endometrial polyps is highly beneficial, particularly for those with abnormal uterine bleeding and infertility. Additionally, polypectomy is indicated to reduce the risk of malignancy. Transvaginal ultrasound is the first-line diagnostic option for detection of endometrial polyps, while sonohysterography has similar accuracy as hysteroscopy in the diagnostic confirmation. Blind dilatation and cure...
Source: Climacteric - Category: Geriatrics Authors: Tags: Climacteric Source Type: research
ConclusionsAs ovarian edema is a rare entity, due to lack of clinical suspicion it is often overdiagnosed as a malignant tumor leading to radical surgery with subsequent loss of hormonal function and early infertility. A high degree of clinical suspicion during the intraoperative period is helpful for diagnosis to avoid unnecessary oophorectomy and infertility.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
The Immp2l mutation causes ovarian aging through ROS-Wnt/β-catenin-estrogen pathway: preventive effect of melatonin. Endocrinology. 2020 Jul 11;: Authors: He Q, Gu L, Lin Q, Ma Y, Liu C, Pei X, Li PA, Yang Y Abstract Mitochondria play important roles in ovarian follicle development. Mitochondrial dysfunction, including mitochondrial gene deficiency, impairs the ovarian development. Here, we explored the role and mechanism of mitochondrial inner membrane gene Immp2l in ovarian follicle growth and development. Our results revealed that the female Immp2l-/- mice were infertile, while the Immp2l+/- m...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research
Psychological domain of quality of life, depression and anxiety levels in in vitro fertilization/intracytoplasmic sperm injection cycles of women with endometriosis: a prospective study. J Psychosom Obstet Gynaecol. 2020 Jul 08;:1-8 Authors: Ceran MU, Yilmaz N, Ugurlu EN, Erkal N, Ozgu-Erdinc AS, Tasci Y, Gulerman HC, Engin-Ustun Y Abstract OBJECTIVE: To evaluate the psychological domain of quality of life (PDQoL), anxiety and depression levels of infertile women with endometriosis versus non endometriosis who applied for Assisted Reproductive Technologies (ART). METHOD: This prospective case-...
Source: Journal of Psychosomatic Obstetrics and Gynaecology - Category: OBGYN Tags: J Psychosom Obstet Gynaecol Source Type: research
Female infertility is a worldwide concern and the etiology of infertility has not been thoroughly demonstrated. Although the mouse is a good model system to perform functional studies, the differences between ...
Source: BMC Genomics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
Abstract Sympathetically mediated contractions of smooth muscle cells in vasa deferentia are mediated by neuronally released adenosine 5'-triphosphate (ATP) and noradrenaline, which stimulate P2X1-purinoreceptors and α1A-adrenoceptors respectively. This process is crucial for sperm transport, as demonstrated in knockout mouse studies where simultaneous genetic deletion of P2X1-purinoreceptors and α1A-adrenoceptors resulted in male infertility. We hypothesise that dual pharmacological antagonism of these two receptors could inhibit sperm transport sufficiently to provide a novel non-hormonal method of m...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
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