A novel methotrexate protocol for the resolution of tubal ectopic pregnancies; Methodological issues on prognostic studies

I was interested to read the paper by Leonardi M et al. published in the Apr 2020 issue of Eur J Obstet Gynecol Reprod Biol [1]. The authors aimed to evaluate if a decreasing human chorionic gonadotropin (hCG) between day (D) 1 and D7 is an equal or better predictor of tubal ectopic pregnancy (EP) resolution following methotrexate (MTX) treatment than the current standard of care. They used a retrospective cohort study of women with a transvaginal ultrasound (TVS)-confirmed tubal EP. After single-dose MTX treatment, D4/7 hCG ratios were compared with that of D1/D7 in terms of sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) to predict EP resolution.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Correspondence Source Type: research