Epileptogenic Network Formation

Epilepsy is characterized by specific alterations in network organization. The main parameters at the basis of epileptogenic network formation are alterations of cortical thickness, development of pathologic hubs, modification of hub distribution, and white matter alterations. The effect is a reinforcement of brain connectivity in both the epileptogenic zone and the propagation zone. Moreover, the epileptogenic network is characterized by some specific neurophysiologic biomarkers that evidence the tendency of the network itself to shift from an interictal state to an ictal one. The recognition of these features is crucial in planning epilepsy surgery.
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research

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CONCLUSIONS: The polymorphisms of AT1R gene loci rs380400, rs1799870, rs12721273, and rs55707609 are correlated with the susceptibility to epilepsy secondary to cerebral infarction. PMID: 32633380 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: Available online 8 July 2020Source: IRBMAuthor(s): K. Polat, M. Nour
Source: IRBM - Category: Biomedical Engineering Source Type: research
Just under half of pharmacists are not discussing the risks of taking sodium valproate when dispensing the drug to women, and just over half of pharmacists are not providing a patient card warning of the risks, a survey by three epilepsy charities  has found.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
AbstractPurpose of ReviewDespite the increase in the number of novel antiseizure medications over the past 20  years, approximately one-third of patients will not have adequate seizure control on medications. For these patients, additional options need to be considered, including dietary, device, and surgical treatments. In addition, many complementary therapies can be considered as adjunctive treatment, w ith the intent of improving quality of life for persons with epilepsy and potentially allowing for improvement in seizure control.Recent FindingsThis review outlines established and developing treatments for drug-re...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
ConclusionsWe report a new patient with a reported missense mutation, c.2605C  >  T (p.Pro869Ser), who exhibited some infrequent manifestations except common phenotypes, which may broaden the known clinical spectrum. Additionally, by reviewing the literature, we also found that patients with missense mutations have a higher incidence of seizures, MRI abnormalities, autistic fe atures and cardiac anomalies. They also have more severe ID and hypotonia. Our case further demonstrates that Pro869Ser is a hotspot mutation of theMED13L gene.
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
Conclusions: IEDs might disrupt the default mode network (DMN). Aberrant brain activities in BECTS patients without IEDs were associated with cognitive areas of the brain. The strength of gamma oscillations in the chronic epilepsy state reflected the duration of BECTS.Significance: MEG could reveal the aberrant neural activities in BECTS patients during the interictal period, and such abnormality is frequency-dependent. Gamma oscillations could be used to identify BECTS patients without IEDs.
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Publication date: October 2020Source: Epilepsy &Behavior, Volume 111Author(s): Martin Salinsky, Laurence Binder, Daniel Storzbach, Karen Parko, Paul Rutecki, Elizabeth Goy, Sandy Tadrous-Furnanz
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: October 2020Source: Epilepsy &Behavior, Volume 111Author(s): Patsy Ramey, Melissa Osborn, Howard Kirshner, Bassel Abou-Khalil
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: October 2020Source: Epilepsy &Behavior, Volume 111Author(s): Ioannis Karakis, Nicholas J. Janocko, Matthew L. Morton, Olivia Groover, Diane L. Teagarden, Hannah K. Villarreal, David W. Loring, Daniel L. Drane
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 8 July 2020Source: Epilepsy &BehaviorAuthor(s): Andreja Packard, Ramon Bautista, Carmen Smotherman, Shiva Gautham
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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