New insights into the core Hippo signaling and biological macromolecules interactions in the biology of solid tumors

AbstractAs an evolutionarily conserved pathway, Hippo signaling pathway impacts different pathology and physiology processes such as wound healing, tissue repair/size and regeneration. When some components of Hippo signaling dysregulated, it affects cancer cells proliferation. Moreover, the relation Hippo pathway with other signaling including Wnt, TGF β, Notch, and EGFR signaling leaves effect on the proliferation of cancer cells. Utilizing a number of therapeutic approaches, such as siRNAs and long noncoding RNA (lncRNA) to prevent cancer cells through the targeting of Hippo pathways, can provide new insights into cancer target therapy. The pur pose of present review, first of all, is to demonstrate the importance of Hippo signaling and its relation with other signaling pathways in cancer. It also tries to demonstrate targeting Hippo signaling progress in cancer therapy.

Source: BioFactors - May 21, 2020 Category: Biochemistry Authors: Solmaz Mohammadi, Reza Arefnezhad, Shahla Danaii, Mehdi Yousefi Tags: Review Article Source Type: research