Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3 ‐Driven Inflammation and Gouty Arthritis

ConclusionOur results present β‐carotene as a selective and direct inhibitor of NLRP 3, and the binding of β‐carotene to NLRP 3 PYD as a novel pharmacologic strategy to combat NLRP 3 inflammasome–driven diseases, including gouty arthritis.

Source: Arthritis and Rheumatology - May 26, 2020 Category: Rheumatology Authors: Gabsik Yang, Hye E. Lee, Su ‐Jin Moon, Kyung M. Ko, Jung H. Koh, Jin K. Seok, Jun‐Ki Min, Tae‐Hwe Heo, Han C. Kang, Yong‐Yeon Cho, Hye S. Lee, Katherine A. Fitzgerald, Joo Y. Lee Tags: Original Article Source Type: research