Local Recurrence Due to Rectal Cancer in Sweden

Condition:   Rectal Neoplasms Intervention:   Procedure: Treatment for local recurrence with surgery or other treatments Sponsor:   Sahlgrenska University Hospital, Sweden Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Publication date: Available online 11 July 2020Source: Pathology - Research and PracticeAuthor(s): JE Ruisch, M Kloft, GE Fazzi, J Melenhorst, D Magee, HI Grabsch
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionThis study identified the preoperative serum hemoglobin level, the distance between the tumor and the anal verge, the type of surgical procedure, hysterectomy, and bilateral oophorectomy as predictors of post-LAR RVF. A nomogram was successfully developed. It could aid in the prediction of RVF in patients undergoing LAR.
Source: Surgery Today - Category: Surgery Source Type: research
Improving pathological complete response (pCR) rates after neoadjuvant chemoradiotherapy for locally advanced rectal cancer may facilitate surgery-sparing treatment paradigms. Radiotherapy boost has been linked to higher rates of pCR; however, outcomes in moderately escalated inverse-planning studies have not been systematically evaluated. We therefore carried out a systematic review and meta-analysis of radiation dose-escalation studies in the context of neoadjuvant therapy for locally advanced rectal cancer.
Source: Clinical Oncology - Category: Radiology Authors: Tags: Overview Source Type: research
To date, only limited magnetic resonance imaging (MRI) data are available concerning tumor regression during neoadjuvant radiochemotherapy (RCT) of rectal cancer patients, which is a prerequisite for adaptive ...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Both frailty and older age are risk factors for adverse surgical outcomes. We hypothesized that frailty, regardless of patient age, is a predictor of poor postoperative outcome among patients with rectal cancer undergoing proctectomy.
Source: Surgery - Category: Surgery Authors: Source Type: research
This study was aimed to investigate the correlation between preoperative prognostic nutritional index (PNI) and permanent stoma (PS) in patients with defunctioning stoma (DS) after anterior resections and, based on it, to reveal the clinical value of PNI on clinical strategies about the selection of stoma location.MethodsA total of 281 consecutive rectal cancer patients who accepted anterior resection and DS in the National Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University from June 2008 to June 2018 were enrolled in this study. Receiver operating characteristic (ROC) curve for P...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: mrTRG may predict OS and DFS comparably or even better compared to pTRG. The addition of DWI on T2-weighted MRI may improve interobserver agreement on mrTRG. PMID: 32643333 [PubMed - as supplied by publisher]
Source: Korean Journal of Radiology - Category: Radiology Tags: Korean J Radiol Source Type: research
This study aims to analyse the surgical results in terms of completion of TME, short-term surgical outcomes and hospital stay in after open, laparoscopic- and robotic-assisted rectal resections respectively. A retrospective review of prospectively maintained database of patients operated for carcinoma rectum between January 2013 and August 2018 at Manipal Comprehensive Cancer Centre, Manipal-Vattikuti Institute of Robotic Surgery, Bangalore, was analysed in this study. The surgical parameters like completion of total mesorectal excision; proximal, distal and circumferential resection margins; number of nodes retrieved; and...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
AbstractBackgroundPrevious studies investigating the impact of tumor location on colorectal cancer prognosis only compared two groups by location, e.g., ‘right-sided colon vs. left-sided colon,’ ‘colon vs. rectum,’ and ‘right-sided (right-sided colon) vs. left-sided (left-sided colon and rectum).’ This nationwide multicenter retrospective study aimed to clarify the prognostic impact of tumor location in patients with stage III colorectal cancer by classifying tumors into three groups: right-sided colon, left-sided colon, and rectum.MethodsSubjects were 9194 patients with stage III colore...
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
CONCLUSION: The study failed to meet the required 3 pCRs in the first 18 pts. The DFS in this population is encouraging and supports the hypothesis that select pts with rectal cancer may be spared from radiation. PMID: 32649004 [PubMed - as supplied by publisher]
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
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