Outcome of Childhood Acute Myeloid Leukemia With FLT3-ITD Mutation: The Experience of Children ’s Cancer Hospital Egypt, 2007-17

In an analysis of the outcome of pediatric acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutation over 10 years at Children ’s Cancer Hospital Egypt, we found that FLT3-ITD mutation was associated with poor outcomes, and survival of patients who experienced relapse was extremely poor. Allogeneic bone marrow transplantation while the patient is experiencing first remission was the best treatment option. FLT3 inhibitors are needed to improve the outcome in AML in developing countries.

Source: Clinical Lymphoma, Myeloma and Leukemia - April 20, 2020 Category: Hematology Authors: Samah Fathy Semary, Mahmoud Hammad, Sonya Soliman, Dina Yassen, Marwa Gamal, Doaa Albeltagy, Nayera Hamdy, Sonia Mahmoud Tags: Original Study Source Type: research