Pharmacokinetic Assessment of Pre- and Post-Oxygenator Vancomycin Concentrations in Extracorporeal Membrane Oxygenation: A Prospective Observational Study

ConclusionsExtracorporeal membrane oxygenation flow rates did not influence vancomycin clearance between flow rates of 3500 and 5000  mL/min and vancomycin was not sequestered in ECMO. Common vancomycin regimens resulted in suboptimal efficacy and/or excessive toxicity. Individual therapeutic drug monitoring is recommended for patients on ECMO.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research