Transcriptional information underlying the generation of CSCs and the construction of a nine-mRNA signature to improve prognosis prediction in colorectal cancer.

CONCLUSIONS: We developed a novel model that provides additional and powerful prognostic information beyond conventional clinicopathological factors for CRC survival prediction. It also provides new insight into the molecular mechanisms underlying the transition from normal tissues to CSCs and formation of tumor tissues.
PMID: 32453965 [PubMed - as supplied by publisher]

Source: Cancer Biology and Therapy - May 25, 2020 Category: Cancer & Oncology Authors: Zheng W, Yang C, Qiu L, Feng X, Sun K, Deng H Tags: Cancer Biol Ther Source Type: research