Effect of genistein and estradiol on the adrenal cortex of the ovariectomized adult female albino rats.

Effect of genistein and estradiol on the adrenal cortex of the ovariectomized adult female albino rats. Folia Morphol (Warsz). 2020 May 27;: Authors: Yassa HD, Safwat NM, Ahmed RM, Fathy MZ, Metry HL Abstract Genistein, a naturally occurring soy isoflavone, attracts interest as an effective and safe alternative to hormone replacement therapy for menopausal proplems. The aim of the current study was to compare between the effect of genistein and estradiol on the adrenal cortex of the ovariectomized adult female albino rats. Twenty rats were used in the current study and divided into 4 groups, five rats in each group; group 1 (control nonovariectomized), group 2 (ovariectomized), group 3 (ovariectomized + genistein) and group 4 (ovariectomized+ estradiol). The rats were sacrificed after 4 weeks. Both adrenal glands were removed for light microscope using Hx & E. stain, ultrastructural study and immunohistochemical examination using PCNA, caspase-3, and ER-β. Ovariectomized rats showed signs of degeneration in all zones of adrenal cortex. On the other hand, Treatment with genistein showed restoration of the adrenal cortex with less proliferative effect than estradiol. So, genistein can be used as effective therapy to decrease the symptoms of menopause without fear of cancer development. PMID: 32459363 [PubMed - as supplied by publisher]
Source: Folia Morphologica - Category: Anatomy Tags: Folia Morphol (Warsz) Source Type: research