Key role of the 5-HT1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment.

Conclusion: These data support the concept that Yif1B plays a critical role in 5-HT1AR functioning and brain 5-HT homeostasis. The opposite changes in its expression observed in anxious or depressive states and after therapeutic fluoxetine treatment suggest that Yif1B might be involved in vulnerability to anxiety and depression, and fluoxetine efficacy. PMID: 32459080 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32459080?dopt=Abstract

Source: Journal of Psychiatry and Neuroscience - May 28, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research