Contactin-1 autoimmunity: Serologic, neurologic, and pathologic correlates

Conclusion
Contactin-1 IgG has a distinct sensory predominant presentation commonly associated with neuropathic pain, with demyelinating changes on electrophysiologic studies. A paraneoplastic cause should be considered. Testing of contactin-1 IgG among cases with similar presentations may guide immunotherapy selection, especially second-line immunotherapy consideration.

Source: Neurology Neuroimmunology and Neuroinflammation - May 26, 2020 Category: Neurology Authors: Dubey, D., Honorat, J. A., Shelly, S., Klein, C. J., Komorowski, L., Mills, J. R., Brakopp, S., Probst, C., Lennon, V. A., Pittock, S. J., McKeon, A. Tags: Autoimmune diseases, Peripheral neuropathy, Chronic inflammatory demyelinating polyneuropathy, Neuropathic pain Article Source Type: research