Cancers, Vol. 12, Pages 1379: The Role of Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer Risk

Cancers, Vol. 12, Pages 1379: The Role of Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer Risk Cancers doi: 10.3390/cancers12061379 Authors: Ippokratis Messaritakis Asimina Koulouridi Maria Sfakianaki Konstantinos Vogiatzoglou Nikolaos Gouvas Elias Athanasakis John Tsiaoussis Evangelos Xynos Dimitriοs Mavroudis Maria Tzardi John Souglakos Vitamin D deficiency has been associated with increased colorectal cancer (CRC) incidence risk and mortality. Vitamin D mediates its action through the binding of the vitamin D receptor (VDR), and polymorphisms of the VDR might explain these inverse associations. The aim of the study was the investigation of the relevance of rs731236; Thermus aquaticus I (TaqI), rs7975232; Acetobacter pasteurianus sub. pasteurianus I (ApaI), rs2228570; Flavobacterium okeanokoites I (FokI) and rs1544410, Bacillus stearothermophilus I (BsmI) polymorphisms of the VDR gene to colorectal carcinogenesis (CRC) and progression. Peripheral blood was obtained from 397 patients with early operable stage II/III (n = 202) and stage IV (n = 195) CRC. Moreover, samples from 100 healthy donors and 40 patients with adenomatous polyps were also included as control groups. Genotyping in the samples from patients and controls was performed using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP). A significant association was revealed between all four polymorphisms and cancer. Individuals with homozygous mutant...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research