The origins of the fight against rabies: a journey between the history of neuroscience and university museum collections.

The origins of the fight against rabies: a journey between the history of neuroscience and university museum collections. Funct Neurol. 2019 Jul/Sep;34(3):196-204 Authors: Garbarino MC Abstract Although rabies, or hydrophobia, is one of the so-called forgotten tropical diseases, it still kills thousands of people each year, especially children living in rural areas of Asia and Africa. This terrible disease was once a much-feared threat throughout Europe, whose terrifying symptoms were described in a vast body of literature that was based on both science and popular beliefs. One notable individual whose name is linked to the fight against this disease is Adelchi Negri, a brilliant but unfortunate pupil of Camillo Golgi. At the beginning of the 20th century, Negri observed peculiar formations in the brains of infected animals: known as Negri's bodies, these formations became an important diagnostic tool used in anti-rabies institutes all over the world. PMID: 32454001 [PubMed - as supplied by publisher]
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research

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Publication date: September 2020Source: Molecular Immunology, Volume 125Author(s): Shu Qing Liu, Xin Gao, Yuan Xie, Qian Wang, Wu Yang Zhu
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Abstract For centuries, people believed that bats possessed sinister powers. Bats are thought to be ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most recently SARS-CoV-2 coronavirus. However, bats themselves tolerate these viruses without ill effects. The second power that bats have is their longevity. Bats live much longer than similar-sized land mammals. Here we review how bats' ability to control inflammation may be contributing to their longevity. The underlying mechanisms may hold clues to developing new treatments for age-related diseases. Now may be the time to use sc...
Source: Cell Metabolism - Category: Cytology Authors: Tags: Cell Metab Source Type: research
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Source: Biotechnology Progress - Category: Biotechnology Authors: Tags: RESEARCH ARTICLE Source Type: research
Kanika Goyal, Chandana Bhagwat, Renu Suthar, Arushi Gahlot Saini, Namita Ravikumar, Paramjeet Singh, Reeta S Mani, Meenu SinghNeurology India 2020 68(3):673-676Rabies encephalitis is a universally fatal disease. Prolonged survival in children with rabies encephalitis has only been anecdotally reported. Case report: An 11-year-old boy presented with right-handed paraesthesia followed by flaccid weakness, progressive quadriparesis and encephalopathy following an unprovoked, class III dog bite over the right wrist 1 month previously. He received five doses of the rabies vaccine as post exposure prophylaxis. Diagnosis of rabie...
Source: Neurology India - Category: Neurology Authors: Source Type: research
Conclusion RESLES manifests as variety of symptoms with less specificity and precipitating factors. Paroxysmal blurred vision may be a relatively specific symptom of RESLES. Levetiracetam, carbamazepine or valproate could be the cause of RESLES, exposure to the rabies vaccine could be another predisposing factors for RESLES as well. RESLES type 1 was therefore found to be highly "reversible" with an excellent prognosis. PMID: 32611957 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
(Field Museum) While scientists are trying to find a vaccine for COVID-19, the rabies virus continues to kill 59,000 people every year. But unlike COVID, a vaccine has existed for more than a century. Vaccinating dogs can stop the spread to humans, but systemic challenges make that easier said that done. In a new study, scientists where grassroots campaigns to stop rabies work-- and where they need to be coupled with large-scale efforts.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
The objective of this study was to determine the reasons why patients in the US do not complete rabies treatment.Methods: We performed a retrospective study to evaluate rabies post-exposure prophylaxis completion in the emergency department of an academic suburban hospital between June 2014 –  July 2017. Further review was performed for patients who received inadequate vaccination to determine the cause of treatment incompletion....
Source: Western Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
Conclusions/SignificanceThe evolution of the Laikipia Rabies Vaccination Campaign from a localized volunteer-effort to a large-scale program attempting to eliminate rabies at the landscape scale provides a unique opportunity to examine successes, failures, and challenges facing grassroots campaigns. Success, in the form of vaccinating more dogs across the study area, was relatively straightforward to achieve. However, lack of effective post-vaccination monitoring and education programs, limited funding, and working in diverse community types appeared to hinder achievement of 70% coverage levels. These results indicate that...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract The blood-brain barrier (BBB) restricts access to the brain of more than 98% of therapeutic agents and is largely responsible for treatment failure of glioblastoma multiforme (GBM). Therefore, it is of great importance to develop a safe and efficient strategy for more effective drug delivery across the BBB into the brain. Inspired by the extraordinary capability of rabies virus (RABV) to enter the central nervous system, we report the development and evaluation of the metal-organic framework-based nanocarrier MILB@LR, which closely mimicked both the bullet-shape structure and surface functions of natural ...
Source: Angewandte Chemie - Category: Chemistry Authors: Tags: Angew Chem Int Ed Engl Source Type: research
Source: PharmacoEconomics and Outcomes News - Category: Drugs & Pharmacology Source Type: news
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