Toxicological testing of a photoactive phthalocyanine-based antimicrobial substance.
Toxicological testing of a photoactive phthalocyanine-based antimicrobial substance.
Regul Toxicol Pharmacol. 2020 May 23;:104685
Authors: Kejlová K, Bendová H, Chrz J, Dvořáková M, Svobodová L, Vlková A, Kubáč L, Kořínková R, Černý J, Očadlíková D, Rucki M, Heinonen T, Jírová D, Letašiová S, Kandarova H, Kolářová H
Abstract
The aim of the study was toxicological testing of an innovative and efficient antimicrobial agent based on photoactive phthalocyanine (Pc) derivative. A promising Aluminium phthalocyanine (AlPc) with efficient and stable antimicrobial effects was subjected to a battery of toxicological tests to avoid local and systemic toxicity hazard. In compliance with the current European legislation restricting the use of experimental animals, the methods comprised exclusively in vitro procedures based on cellular and tissue models of human origin or mimicking human tissues. The battery of toxicological tests to identify local toxicity included skin corrosion/irritation, eye irritation, and phototoxicity. The basic systemic toxicity tests included acute toxicity, skin sensitization, genotoxicity, and endocrine disruption. The results showed that AlPc induced skin and eye irritation, exhibited borderline sensitization potential and mutagenic potential in one test strain of the Ames test, which was not confirmed in the chromosome aberration test. The AlPc was found to be phototoxic. The results from the ...
Source: Regulatory Toxicology and Pharmacology : RTP - Category: Toxicology Authors: Kejlová K, Bendová H, Chrz J, Dvořáková M, Svobodová L, Vlková A, Kubáč L, Kořínková R, Černý J, Očadlíková D, Rucki M, Heinonen T, Jírová D, Letašiová S, Kandarova H, Kolářová H Tags: Regul Toxicol Pharmacol Source Type: research