Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein –protein interactions

Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00928H, CommunicationHao Shao, Keely Oltion, Taia Wu, Jason E. Gestwicki Homo-oligomers are difficult drug targets. Here, Differential Scanning Fluorimetry (DSF) is introduced as a method to identify inhibitors of these systems, by discriminating between oligomers and monomers based on their thermal stability. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research