Gastroesophageal Reflux Poses a Potential Risk for Late Complications of Bronchopulmonary Dysplasia: A Prospective Cohort Study.

Gastroesophageal Reflux Poses a Potential Risk for Late Complications of Bronchopulmonary Dysplasia: A Prospective Cohort Study. Chest. 2020 May 22;: Authors: Wang LJ, Hu Y, Wang W, Zhang CY, Bai YZ, Zhang SC Abstract BACKGROUND: Bronchopulmonary dysplasia (BPD) is the most common respiratory disorder in extremely low birth weight infants. Although most BPD symptoms improve, some late complications exist, even with regular treatment. Gastroesophageal reflux (GER), also common in extremely premature infants, may be related to many cardiorespiratory symptoms. However, the potential of GER as a risk factor for late complications associated with BPD is still unclear. RESEARCH QUESTION: Does GER increase the risk of late complications of BPD in infants? STUDY DESIGN: and Methods: A multi-center prospective cohort of 131 infants (79 males, 52 females) with BPD was enrolled. The development of late complications was assessed over an 18-month follow-up. A 24h pH-multichannel intraluminal impedance (pH-MII) and gastric sodium concentration were analyzed in all infants at 36 weeks' postmenstrual age and at the last interview. Prevalence and risk factors of late complications of BPD were analyzed by forward logistic regression. RESULTS: The prevalence of late complications in BPD infants was 63.79% and included respiratory symptoms (49.14%), vomiting (38.79%), retinopathy of prematurity (ROP, 25.86%), hypoxic-ischemic in...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research