Clinical phenotypes of atopy and asthma in COPD: a meta-analysis of SPIROMICS and COPDGene.

Clinical phenotypes of atopy and asthma in COPD: a meta-analysis of SPIROMICS and COPDGene. Chest. 2020 May 22;: Authors: Putcha N, Fawzy A, Matsui EC, Liu M, Bowler RP, Woodruff P, O'Neal WK, Comellas AP, Han MK, Dransfield M, Wells JM, Lugogo N, Gao L, Talbot CC, Hoffman E, Cooper CB, Paulin LM, Kanner RE, Criner G, Ortega VE, Barr RG, Krishnan JA, Martinez FJ, Drummond MB, Wise RA, Diette GB, Hersh CP, Hansel NN Abstract BACKGROUND: Little is known about the concordance of atopy with asthma COPD overlap (ACO). Among individuals with COPD, a better understanding of the phenotypes characterized by asthma overlap and atopy is needed to better target therapies. RESEARCH QUESTION: What is the overlap between atopy and asthma status among individuals with COPD, and how are categories defined by the presence of atopy and asthma status associated with clinical and radiologic phenotypes and outcomes in the SPIROMICS and COPDGene studies? STUDY DESIGN AND METHODS: 403 individuals with COPD from SPIROMICS and 696 individuals from COPDGene with data about specific IgEs to 10 common allergens and mixes (simultaneous assessment of combination of allergens in similar category) were included. Comparison groups were defined by atopic and asthma status (neither, atopy alone, atopic asthma, non-atopic asthma, with atopy defined as any positive specific IgE (>0.35 KU/L) to any of the 10 allergens or mixes and asthma defined as self...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research