Comparison of volatile organic compound profiles in exhaled breath versus plasma headspace in different diseases

In this study we investigated the relationship between
22 VOC's detected in exhaled breath and plasma headspace using a selected ion flow tube mass
spectrometer (SYFT-MS). We compared pairs of exhaled breath and plasma samples from patients with
pulmonary hypertension inflammatory bowel disease (IBD), and IBD patients after J-pouch surgery
(pouch group). Half of the measured VOC's from exhaled breath were significantly associated with the
VOC's from plasma headspace. Interestingly, six breath VOC's (trimethyl amine (FDR p = 0.02),
hydrogen sulfide (FDR p = 7.64 ×

Source: Journal of Breath Research - May 25, 2020 Category: Respiratory Medicine Authors: David Grove, Galen Miller-Atkins, Celia Melillo, Florian Rieder, Satya Kurada, Daniel M Rotroff, Adriano R Tonelli and Raed A Dweik Source Type: research