Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells.

CONCLUSIONS: These results suggest that circulating EVs can modulate endothelial integrity contributing to the development of ACS in SCD patients by altering cadherin-containing intercellular junctions.
IMPACT: Sickle cell disease patients have circulating extracellular vesicles (EVs) that modulate endothelial integrity by altering cadherin-containing intercellular junctions.Disruption is more severe by EVs obtained during acute chest syndrome (ACS).These results expand our knowledge of the pathophysiology of acute chest syndrome and the vasculopathies of sickle cell disease.
PMID: 32454519 [PubMed - as supplied by publisher]

Source: Pediatric Research - May 25, 2020 Category: Pediatrics Authors: Lapping-Carr G, Gemel J, Mao Y, Sparks G, Harrington M, Peddinti R, Beyer EC Tags: Pediatr Res Source Type: research