Pathophysiology of the Venous Thromboembolism Risk in Preeclampsia.

Pathophysiology of the Venous Thromboembolism Risk in Preeclampsia. Hamostaseologie. 2020 May 25;: Authors: Kelliher S, Maguire PB, Szklanna PB, Weiss L, Ewins K, O'Doherty R, Angelov D, Ní Áinle F, Kevane B Abstract Haemostatic derangements are a hallmark of preeclampsia and appear to favour an increased risk of venous thromboembolism. However, haemorrhagic complications have also been reported. The mechanisms underlying these competing risks remain to be fully elucidated although recent work has highlighted the role of placental factors, such as extra-cellular vesicles and inflammatory mediators, in modulating these haemostatic derangements as well as driving progression of preeclampsia. Identifying affected women at risk of thrombosis and managing the competing thrombotic and haemorrhagic risks continue to be a significant clinical challenge. Derangements in blood coagulation are also implicated in the pathogenesis of preeclampsia; however, the role of antiplatelet or anticoagulant drugs in the management of this disorder remains a source of debate. Further characterisation of the underlying molecular mechanisms would likely be of major translational relevance and could provide insights into the pathogenesis of this disease as well as the associated haemostatic dysfunction.Preeclampsia complicates up to 8% of pregnancies and is a leading cause of fetomaternal morbidity andmortality. Treatment options are limited, with supportive...
Source: Hamostaseologie - Category: Hematology Authors: Tags: Hamostaseologie Source Type: research