FLAER-negative CD15+ neutrophils can be used for the simplified screening of suspected PNH cases.

CONCLUSION: This simple two-color evaluation of FLAER-negative neutrophils is a highly effective screening test for PNH. Although this approach is not intended to replace the multicolor diagnostic procedure, it could minimize the number of patients requiring a conventional multicolor flow cytometric assay.
PMID: 32449605 [PubMed - as supplied by publisher]

Source: International Journal of Laboratory Hematology - May 24, 2020 Category: Hematology Authors: Semchenkova A, Kashpor S, Verzhbitskaya T, Borisov V, Illarionova O, Fechina L, Maschan A, Novichkova G, Popov A Tags: Int J Lab Hematol Source Type: research