HIV-1 Tat-mediated astrocytic amyloidosis  involves the HIF-1α/lncRNA BACE1-AS axis

We report here, in simian immunodeficiency virus (SIV)+ rhesus macaques and patients diagnosed with HIV, brain region–specific up-regulation of amyloid precursor protein (APP) and Aβ (40 and 42) in astrocytes. In addition, we find increased expression of β-site cleaving enzyme (BACE1), APP, and Aβ in human primary astrocytes (HPAs) exposed to Tat. Mechanisms involved up-regulation of hypoxia- inducible factor (HIF-1α), its translocation and binding to the long noncoding RNA (lncRNA) BACE1‚Äźantisense transcript (BACE1-AS), resulting, in turn, in the formation of the BACE1-AS/BACE1 RNA complex, subsequently leading to increased BACE1 protein, and activity and generation of Aβ-42. Gene s ilencing approaches confirmed the regulatory role of HIF-1α in BACE1-AS/BACE1 in Tat-mediated amyloidosis. This is the first report implicating the role of the HIF-1α/lncRNABACE1-AS/BACE1 axis in Tat-mediated induction of astrocytic amyloidosis, which could be targeted as adjunctive therapies for HAND-associated Alzheimer-like comorbidity.
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research

Related Links:

In this study, we investigated the potential effects of disocin on amyloid-β peptide (Aβ1-42) oligomers-treated HT22 cells. Aβ1-42 oligomers induced great neurotoxicity to HT22 cells as examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results of terminal deoxynucleoitidyl transferase-mediated deoxyuridine triphosphate biotin nich end labeling (TUNEL) staining and flow cytometry indicated that Aβ1-42 oligomers led to increased apoptosis and generation of reactive oxygen species (ROS) in HT22 cells. However, dioscin could remarkably inhibit the neurotoxicity induce...
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
Publication date: Available online 3 August 2020Source: Stem Cell ResearchAuthor(s): He Shan, Jin Ye, Xing Hai Ping, He XinYue, Zhang ShuYang
Source: Stem Cell Research - Category: Stem Cells Source Type: research
This study is preliminary but findings are interesting, which is a first step to provide quantifiable evidences to measure sleep as a risk factor of AD. PMID: 32308848 [PubMed - indexed for MEDLINE]
Source: AMIA Annual Symposium Proceedings - Category: Bioinformatics Tags: AMIA Annu Symp Proc Source Type: research
Authors: PMID: 32743933 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
CONCLUSION: Our results demonstrate that hearing loss is indepedently associated with lower microstructural integrity in brain regions that are important for different cognitive processes. PMID: 32743902 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: Available online 3 August 2020Source: Life Sciences in Space ResearchAuthor(s): Laura Owlett, Elizabeth K. Belcher, Dawling A. Dionisio-Santos, Jacqueline P. Williams, John A. Olschowka, M. Kerry O'Banion
Source: Life Sciences in Space Research - Category: Biology Source Type: research
Publication date: 15 January 2021Source: Journal of Hazardous Materials, Volume 402Author(s): Giselle V. Sousa, Vânia L.G. Teles, Eduardo G. Pereira, Luzia V. Modolo, Letícia M. Costa
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
PSCI shows a high incidence on acute stage, and more than a half (54.4%) of patients suffered with PSCI. Reduced serum thiamine was associated with early cognitive impairment in patients with acute infarction after adjusting for potential confounding factors. Advanced age, lower education, diabetes mellitus, left hemisphere infarction, and higher NIHSS were also independent risk factors for PSCI. AbstractObjectiveReduced thiamine (vitamin B1) had been reported to be associated with cognitive impairment caused by Alzheimer disease. Our study is to explore the association between thiamine and cognitive impairment after acute...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Photo credit Behard Grossgasteiger Hiring in-home care for my neighbor, Joe, was quite an ordeal. The company we chose and their caregivers were great, but the quality of care wasn't the issue. The problem was that Joe resented anyone but me helping him. He locked one caregiver out of his home, let another in but was rude to her, and thoroughly enjoyed one young man, but only because they could discuss golf together. Families hire home care to provide respite and quality care for seniors, but what is a caregiver to do when their loved one refuses to cooperate with this new addition to their care plan? Continue re...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
More News: Alzheimer's | Amyloidosis | Biology | Brain | Genetics | Neurology | Pathology | Toxicology | Translocation