Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation [Medical Sciences]
Alcohol-related liver disease (ALD) accounts for the majority of cirrhosis and liver-related deaths worldwide. Activation of IFN-regulatory factor (IRF3) initiates alcohol-induced hepatocyte apoptosis, which fuels a robust secondary inflammatory response that drives ALD. The dominant molecular mechanism by which alcohol activates IRF3 and the pathways that amplify inflammatory signals in...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Jay Luther, Sanjoy Khan, Manish K. Gala, Dmitry Kedrin, Gautham Sridharan, Russell P. Goodman, John J. Garber, Ricard Masia, Erik Diagacomo, Daniel Adams, Kevin R. King, Samuel Piaker, Hans-Christian Reinecker, Martin L. Yarmush, Josepmaria Argemi, Ramon Tags: Biological Sciences Source Type: research
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