Genital Powder Use and Ovarian Cancer —Reply

In Reply As pointed out by Dr Cramer, the cohorts in our pooled analysis assessed powder use with less detail compared with prior case-control studies. He is also correct that most participants were postmenopausal at enrollment, although ever use included premenopausal time and we considered menopausal status and hormone use as effect modifiers. We noted that genital powder exposure was likely misclassified for some individuals, especially with regard to frequency and duration, and we did not have data on changes in use over time, use during specific exposure windows, or use of different types of powder. This lack of detail may have biased our effect estimates toward the null.
Source: JAMA - Category: General Medicine Source Type: research