Estimates of the global burden of Japanese Encephalitis and the impact of vaccination from 2000-2015

In this study, we implemented a mathematical modelling method (catalytic model) combined with age-stratifed case data from our systematic review which can overcome some of these limitations. We estimate in 2015 JEV infections caused 100,308 JE cases (95%CI: 61,720 - 157,522) and 25,125 deaths (95%CI: 14,550 - 46,031) globally, and that between 2000 and 2015 307,774 JE cases (95%CI: 167,442- 509,583) were averted due to vaccination globally. Our results highlight areas that could have the greatest benefit from starting vaccination or from scaling up existing programs and will be of use to support local and international policymakers in making vaccine allocation decisions.
Source: eLife - Category: Biomedical Science Tags: Epidemiology and Global Health Source Type: research