Five new C17/C15 sesquiterpene lactone dimers from Carpesium abrotanoides.

Five new C17/C15 sesquiterpene lactone dimers from Carpesium abrotanoides. Fitoterapia. 2020 May 22;:104630 Authors: Yang YX, Wang JX, Li HL, Mo Q, Huang HY, Tao M, Luo Q, Liu H Abstract Five new unusual C17/C15 sesquiterpene lactone dimers, carabrodilactones A-E (1-5), along with four known common C15/C15 SLDs, carpedilactones A and B (6 and 7), faberidilactone A (8), and faberidilactone C (9), were isolated from the whole plants of Carpesium abrotanoides. The structures of 1-5 featured a flexible C-11/C-13' linked single bond between two sesquiterpene units and a tailed acetyl connected to the C-13 position. The preferential conformation of 1-5 was elucidated by the diagnostic NMR data of geminal proton of H-13. The biogenetic pathway of 1-5 was proposed to involve a Michael addition reaction. In addition, compound 1 exhibited significant cytotoxicities against the four cell lines (A549, HCT116, MDA-MB, and BEL7404 cells) with IC50 value in the range of 3.08-8.05 μM, while compounds 2-5 showed weak cytotoxicities. PMID: 32450116 [PubMed - as supplied by publisher]
Source: Fitoterapia - Category: Biochemistry Authors: Tags: Fitoterapia Source Type: research
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