Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages

Myocardial ischaemia is usually accompanied by inflammatory response which plays a critical role in the myocardial healing and scar formation, while persistent inflammatory response contributes greatly to the myocardial remodeling and consequent heart failure. Metformin (Met), a widely used hypoglycemic drug, has increasingly been shown to exert remarkable cardioprotective effect on ischaemic myocardial injury such as acute myocardial infarction (AMI). However, the underlying mechanisms are still far from being fully understood.

Source: Journal of Molecular and Cellular Cardiology - May 24, 2020 Category: Cytology Authors: Qin Fei, Heng Ma, Jiang Zou, Wenmei Wang, Lili Zhu, Huafei Deng, Meng Meng, Sipin Tan, Huali Zhang, Xianzhong Xiao, Nian Wang, Kangkai Wang Source Type: research