Posterolateral lumbar spine fusion with unidirectional porous beta-tricalcium phosphate in a canine model

AbstractWe investigated the use of the autologous iliac bone and unidirectional porous beta-tricalcium phosphate (UDPTCP) in posterolateral lumbar spine fusion (PLF). Ten canine PLF models were prepared. Using only the autologous bone as the control group, 100%, 75%, 50%, and 25% groups were prepared according to the mixing ratios of UDPTCP. Radiological evaluation and histological analysis were performed 12  weeks after surgery. Bone fusion was evaluated according to anteroposterior plain X-rays and coronal reconstruction CT views using four grades: 0 = no osteogenesis, 1 = only slight discontinuous osteogenesis between transverse processes, 2 = discontinuous osteogenesis between transvers e processes, and 3 = continuous osteogenesis between transverse processes. Bone fusion determined by X-ray was 2.8 ± 0.5 in the control group, 0 in the 100% UDPTCP group (p  =  0.02), 1.8 ± 0.5 (p  =  0.03) in the 75% UDPTCP group, 2.5 ± 0.6 (p  =  0.54) in the 50% UDPTCP group, and 2.8 ± 0.5 (p  =  1.0) in the 25% UDPTCP group. The bone fusion score was significantly lower in the 75% and 100% UDPTCP groups than in the control group. Bone fusion determined by CT was 2.8 ± 0.5 in the control group, 1.0 ± 0.8 (p  =  0.01) in the 100% UDPTCP group, 2.0 ± 0.0 (p  =  0.02) in the 75% UDPTCP group, 2.5 ± 0.6 (p  =  0.54) in the 50% UDPTCP group, and 2.8 ± 0.5 (p  =  1.0) in the 25% UDPTCP group. Similar...
Source: Journal of Artificial Organs - Category: Transplant Surgery Source Type: research