Zinc(II)-Catalyzed Synthesis of Secondary Amides from Ketones via Beckmann Rearrangement Using Hydroxylamine-O-sulfonic Acid in Aqueous Media

Synthesis DOI: 10.1055/s-0040-1707809 A zinc(II)-catalyzed single-step protocol for the Beckmann rearrangement using hydroxylamine-O-sulfonic acid (HOSA) as the nitrogen source in water was developed. This direct method efficiently produces secondary amides under open atmosphere in a pure form after basic aqueous workup. It is environmentally benign and operationally simple. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - May 24, 2020 Category: Chemistry Authors: Verma, Saumya Kumar, Puneet Khatana, Anil K. Chandra, Dinesh Yadav, Ajay K. Tiwari, Bhoopendra Jat, Jawahar L. Tags: special topic Source Type: research