IJERPH, Vol. 17, Pages 3742: Initial Therapy, Regimen Change, and Persistence in a Spanish Cohort of Newly Treated Type 2 Diabetes Patients: A Retrospective, Observational Study Using Real-World Data

IJERPH, Vol. 17, Pages 3742: Initial Therapy, Regimen Change, and Persistence in a Spanish Cohort of Newly Treated Type 2 Diabetes Patients: A Retrospective, Observational Study Using Real-World Data International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17103742 Authors: Aida Moreno-Juste Beatriz Poblador-Plou Mercedes Aza-Pascual-Salcedo Francisca González-Rubio Sara Malo Julián Librero López Victoria Pico-Soler Eva Giménez Labrador Sara Mucherino Valentina Orlando Enrica Menditto Alexandra Prados-Torres Antonio Gimeno-Miguel The World Health Organization considers the non-adherence to medication a significant issue with global impact, especially in chronic conditions such as type 2 diabetes. We aim to study antidiabetic treatment initiation, add-on, treatment switching, and medication persistence. We conducted an observational study on 4247 individuals initiating antidiabetic treatment between 2013 and 2014 in the EpiChron Cohort (Spain). We used Cox regression models to estimate the likelihood of non-persistence after a one-year follow-up, expressed as hazard ratios (HRs). Metformin was the most frequently used first-line antidiabetic (80% of cases); combination treatment was the second most common treatment in adults aged 40–79 years, while dipeptidyl peptidase-4 inhibitors were the second most common in individuals in their 80s and over, and in patients with renal disease...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research

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